Stocks/Funds/CIK 1425738

Redmile Group, LLC

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1425738
Assets
$1.51B
+42.7% YoY
Holdings
35
Lifetime alpha vs market
-20.98% annual
Average hold time
4.2 yr
median 3.5 yr

Quarterly history

Cum return -41% vs S&P +52% · α -93% lifetimeAUM $1.5B · peak $8.3BFlow $179M (+13%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-6.13%
trims when stocks drop
when a holding falls −10%+
Middle response
-9.49%
baseline attrition
Rally response
-2.08%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
SRRKScholar Rock Holding Cor$446M29.5%+52.9%8.0 yr
KRYSKrystal Biotech, Inc.$174M11.5%+43.3%7.5 yr
STOKStoke Therapeutics, Inc.$136M9.0%+389.6%7.0 yr
IMNMImmunome, Inc.$122M8.1%+225.0%2.5 yr
NRIXNurix Therapeutics, Inc.$120M7.9%+30.5%5.8 yr
ANNXAnnexon, Inc.$81M5.3%+187.0%5.8 yr
ADCTADC Therapeutics S.A.$58M3.8%+166.0%6.0 yr
RGNXREGENXBIO Inc.$37M2.4%+17.2%9.3 yr
STTKShattuck Labs, Inc.$36M2.4%+576.8%5.5 yr
BEAMBeam Therapeutics Inc.$29M2.0%+22.0%6.3 yr
NGNENeurogene Inc.$29M1.9%+72.2%2.5 yr
COGTCogent Biosciences, Inc.$26M1.8%+542.6%3.0 yr
ABSIAbsci Corporation$25M1.6%+19.5%4.8 yr
IDYAIDEAYA Biosciences, Inc.$17M1.1%+103.4%2.5 yr
ALXOALX Oncology Holdings In$16M1.1%+222.6%5.8 yr

Portfolio composition (YoY)

Industry mix
Biotechnology95.9%+14.6pp$1.45B
Unknown2.8%-6.0pp$42M
Medical - Devices1.3%-8.6pp$20M
Country
US90.6%+8.3pp
CH3.8%+1.8pp
Unknown2.8%-6.0pp
GB1.2%-3.1pp
CA1.0%+0.8pp
CR0.4%-0.9pp
BE0.1%
Top 5: 66.0% · Top 10: 81.9% · Top 25: 97.3%

Winners

TickerPrev $PnLYoY %
STOK$30M+0.12B389.6%
COGT$19M+0.10B542.6%
IMNM$36M+0.08B225.0%
SRRK$141M+0.07B52.9%
KRYS$133M+0.06B43.3%

Losers

TickerPrev $PnLYoY %
CBLL$8M-0.00B-4.6%

Top buys this quarter · 9

SRRK Scholar Rock Holding Corporati+$189M
ANNX Annexon, Inc.+$25M
ALXO ALX Oncology Holdings Inc.+$9M
XENE Xenon Pharmaceuticals Inc.+$7M
PRME Prime Medicine, Inc.+$5M
STOK Stoke Therapeutics, Inc.+$4M
AGMB AgomAb Therapeutics N.V. Amerinew+$2M
new+$0M
+$0M

Top sells this quarter · 15

COGT Cogent Biosciences, Inc.$29M
BMRN BioMarin Pharmaceutical Inc.$18M
REPL Replimune Group, Inc.exit$8M
IDYA IDEAYA Biosciences, Inc.$7M
NRIX Nurix Therapeutics, Inc.$6M
ARDX Ardelyx, Inc.$5M
IMNM Immunome, Inc.$3M
BEAM Beam Therapeutics Inc.$1M
KRYS Krystal Biotech, Inc.$167M
PLRX Pliant Therapeutics, Inc.$1M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$1.51B35+77.00%+17.59%+59.41%+0.18B
2025-12-31$1.36B34+36.24%+17.72%+18.52%-0.06B
2025-09-30$1.03B40-6.41%+17.52%-23.93%-0.12B
2025-06-30$940M48-20.42%+14.94%-35.36%-0.20B
2025-03-31$1.06B56-41.46%+8.30%-49.76%-0.02B
2024-12-31$1.43B62-5.34%+24.89%-30.23%-0.17B
2024-09-30$1.70B63+4.95%+36.04%-31.09%-0.02B
2024-06-30$1.65B63-12.20%+24.49%-36.70%-0.50B
2024-03-31$2.72B77+5.05%+29.62%-24.57%-0.69B
2023-12-31$2.80B70-24.79%+26.18%-50.97%+0.59B
2023-09-30$2.10B68-26.89%+21.57%-48.46%-0.16B
2023-06-30$2.61B72-32.94%+19.42%-52.37%+0.43B
2023-03-31$2.30B76-45.48%-7.82%-37.66%+0.17B
2022-12-31$2.44B69+1.99%+7.56%-5.57%-0.18B
2022-09-30$2.58B70-20.34%-4.93%-15.41%+0.49B
2022-06-30$2.62B71-23.19%-16.11%-7.08%+0.16B