Stocks/Funds/CIK 1595855

Opaleye Management Inc.

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1595855
Assets
$759M
+73.2% YoY
Holdings
54
Lifetime alpha vs market
+3.68% annual
Average hold time
2.1 yr
median 1.0 yr

Quarterly history

Cum return +76% vs S&P +52% · α +24% lifetimeAUM $759M · peak $766MFlow $-9M (-1%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-6.10%
trims when stocks drop
when a holding falls −10%+
Middle response
-4.11%
baseline attrition
Rally response
-5.49%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
HROWHarrow Health, Inc.$100M13.2%+32.6%6.0 yr
LQDALiquidia Corporation$89M11.7%+155.9%5.0 yr
ETONEton Pharmaceuticals, In$71M9.3%+90.1%7.5 yr
SLGLSol-Gel Technologies Ltd$40M5.2%0.8 yr
RYTMRhythm Pharmaceuticals, $35M4.7%+64.2%4.8 yr
$33M4.3%0.8 yr
IRONDisc Medicine, Inc.$27M3.5%+28.8%1.3 yr
URGNUroGen Pharma Ltd.$26M3.4%+62.6%3.3 yr
$24M3.2%0.5 yr
STOKStoke Therapeutics, Inc.$23M3.0%+389.6%1.5 yr
CATXPerspective Therapeutics$19M2.6%+95.8%0.5 yr
RZLTRezolute, Inc.$19M2.5%+5.2%1.8 yr
MGTXMeiraGTx Holdings plc$18M2.4%+27.7%0.8 yr
TGTXTG Therapeutics, Inc.$18M2.3%-15.7%6.5 yr
$17M2.2%1.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology69.9%+6.0pp$530M
Drug Manufacturers - Specialty & Generic13.7%-10.8pp$104M
Unknown13.4%+3.9pp$102M
Medical - Devices2.6%+0.4pp$20M
Medical - Diagnostics & Research0.5%$3M
Country
US81.4%-8.4pp
Unknown13.4%+3.9pp
IL5.2%
Top 5: 44.0% · Top 10: 61.5% · Top 25: 88.2%

Winners

TickerPrev $PnLYoY %
LQDA$33M+0.05B155.9%
HROW$105M+0.03B32.6%
ETON$37M+0.03B90.1%
RYTM$26M+0.02B64.2%
STOK$2M+0.01B389.6%

Losers

TickerPrev $PnLYoY %
CDXS$26M-0.01B-39.4%
TGTX$21M-0.00B-15.7%

Top buys this quarter · 15

URGN UroGen Pharma Ltd.+$21M
MGTX MeiraGTx Holdings plc+$15M
CATX Perspective Therapeutics, Inc.+$15M
IRON Disc Medicine, Inc.+$14M
QTTB Q32 Bio Inc.+$7M
EDIT Editas Medicine, Inc.new+$5M
LQDA Liquidia Corporation+$4M
SLGL Sol-Gel Technologies Ltd.+$4M
BDSX Biodesix, Inc.new+$3M
LYEL Lyell Immunopharma, Inc.new+$2M

Top sells this quarter · 15

HROW Harrow Health, Inc.$38M
CGON CG Oncology, Inc. Common stock$21M
RYTM Rhythm Pharmaceuticals, Inc.$35M
ALKS Alkermes plcexit$17M
OCUL Ocular Therapeutix, Inc.$8M
KPTI Karyopharm Therapeutics Inc.exit$5M
PLX Protalix BioTherapeutics, Inc.$5M
VTYX Ventyx Biosciences, Inc.exit$4M
TECX Tectonic Therapeutic, Inc.$3M
ASRT Assertio Holdings, Inc.exit$3M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$759M54+65.58%+17.59%+47.99%-0.01B
2025-12-31$758M53+41.64%+17.72%+23.92%-0.01B
2025-09-30$703M42+26.79%+17.52%+9.27%+0.01B
2025-06-30$484M39+22.69%+14.94%+7.75%+0.02B
2025-03-31$438M43+3.87%+8.30%-4.44%-0.05B
2024-12-31$561M37+53.82%+24.89%+28.93%-0.02B
2024-09-30$591M42+73.38%+36.04%+37.34%-0.00B
2024-06-30$430M49+4.96%+24.49%-19.54%+0.03B
2024-03-31$456M51+2.84%+29.62%-26.78%-0.02B
2023-12-31$373M45-13.30%+26.18%-39.48%+0.04B
2023-09-30$304M39-13.60%+21.57%-35.17%-0.05B
2023-06-30$417M46+16.31%+19.42%-3.12%+0.13B
2023-03-31$334M41-0.56%-7.82%+7.26%+0.02B
2022-12-31$288M40+9.79%+7.56%+2.23%+0.02B
2022-09-30$242M42+12.65%-4.93%+17.57%-0.01B
2022-06-30$222M47-25.75%-16.11%-9.64%-0.02B