Stocks/Funds/CIK 2050194

Spruce Street Capital LP

Quarterly 13F filings · Latest period 2026-03-31 · CIK 2050194
Assets
$416M
Holdings
28
Lifetime alpha vs market
+456.93% annual
Average hold time
0.4 yr
median 0.5 yr

Quarterly history

Cum return +47% vs S&P -4% · α +51% lifetimeAUM $416M · peak $416MFlow $-29M (-9%)2025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+63.27%
adds when stocks drop
when a holding falls −10%+
Middle response
+28.73%
steady accumulation
Rally response
+2.61%
adds into rallies
when a holding rises +10%+

Top positions · 28

Ticker$ value% portYoYHold time
RLMDRelmada Therapeutics, In$43M10.3%0.5 yr
$37M8.8%0.5 yr
LBRXLB Pharmaceuticals Inc C$34M8.1%0.5 yr
DNTHDianthus Therapeutics, I$31M7.5%0.5 yr
RLAYRelay Therapeutics, Inc.$30M7.1%0.5 yr
ANROAlto Neuroscience, Inc.$29M7.0%0.5 yr
CNTACentessa Pharmaceuticals$19M4.7%0.5 yr
SVRASavara Inc.$18M4.4%0.5 yr
KALVKalVista Pharmaceuticals$18M4.3%0.5 yr
PCVXVaxcyte, Inc.$14M3.4%0.5 yr
ELVNEnliven Therapeutics, In$13M3.1%0.5 yr
$13M3.0%0.5 yr
ENTAEnanta Pharmaceuticals, $12M2.8%0.5 yr
ALKSAlkermes plc$11M2.7%0.3 yr
CATXPerspective Therapeutics$11M2.6%0.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology80.8%$336M
Unknown15.3%$64M
Medical - Devices2.6%$11M
Shell Companies1.2%$5M
Country
US76.1%
Unknown15.3%
GB4.7%
IE2.7%
KY1.2%
Top 5: 41.9% · Top 10: 65.8% · Top 25: 97.2%

Winners

TickerPrev $PnLYoY %

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 15

ANRO Alto Neuroscience, Inc.+$25M
CNTA Centessa Pharmaceuticals plc+$16M
RLMD Relmada Therapeutics, Inc.+$15M
ALKS Alkermes plcnew+$11M
CATX Perspective Therapeutics, Inc.new+$11M
KALV KalVista Pharmaceuticals, Inc.+$10M
LBRX LB Pharmaceuticals Inc Common +$9M
ALMS Alumis Inc. Common Stocknew+$9M
ENTA Enanta Pharmaceuticals, Inc.+$7M
DNTH Dianthus Therapeutics, Inc.+$6M

Top sells this quarter · 9

ERAS Erasca, Inc.$56M
EYPT EyePoint Pharmaceuticals, Inc.exit$13M
PCVX Vaxcyte, Inc.$9M
OCUL Ocular Therapeutix, Inc.exit$7M
ABVX Abivax S.A.exit$5M
ELVN Enliven Therapeutics, Inc.$7M
CDTX Cidara Therapeutics, Inc.exit$0M
CYBN Cybin Inc.exit$0M
exit$0M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$416M28+46.91%-4.37%+51.28%-0.03B
2025-12-31$303M27