Stocks/Funds/CIK 2013341

Foresite Capital Management VI LLC

concentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 2013341
Assets
$460M
+152.1% YoY
Holdings
17
Lifetime alpha vs market
+42.88% annual
Average hold time
0.8 yr
median 0.5 yr

Quarterly history

Cum return +76% vs S&P +13% · α +63% lifetimeAUM $460M · peak $460MFlow $-48M (-14%)2024-122025-032025-062025-092025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+12.58%
adds when stocks drop
when a holding falls −10%+
Middle response
-0.35%
baseline attrition
Rally response
-4.08%
trims into rallies
when a holding rises +10%+

Top positions · 17

Ticker$ value% portYoYHold time
CGONCG Oncology, Inc. Common$150M32.7%+176.4%1.5 yr
ALMSAlumis Inc. Common Stock$94M20.3%+258.8%1.5 yr
CNTACentessa Pharmaceuticals$54M11.8%+176.2%1.5 yr
CRVSCorvus Pharmaceuticals, $27M5.8%+360.1%1.5 yr
DNLIDenali Therapeutics Inc.$23M5.0%+41.2%0.8 yr
AGIOAgios Pharmaceuticals, I$18M3.9%+15.5%0.5 yr
0LOV.LVerastem, Inc.$17M3.6%1.0 yr
KYMRKymera Therapeutics, Inc$12M2.6%+204.3%1.5 yr
NERVMinerva Neurosciences, I$12M2.6%+254.7%0.3 yr
CLDXCelldex Therapeutics, In$10M2.2%+74.8%0.3 yr
$10M2.1%0.3 yr
HNGEHinge Health, Inc.$8M1.8%1.0 yr
CRNXCrinetics Pharmaceutical$8M1.7%+8.3%0.3 yr
OKUROnKure Therapeutics, Inc$6M1.3%-3.7%0.3 yr
JBIOJade Biosciences, Inc.$4M1.0%0.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology95.5%+8.0pp$439M
Unknown2.7%-7.2pp$12M
Medical - Healthcare Information Services1.8%$8M
Country
US84.6%+4.4pp
GB11.8%+1.9pp
Unknown2.7%-7.2pp
IE1.0%
Top 5: 75.6% · Top 10: 90.5% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
CGON$54M+0.10B176.4%
ALMS$26M+0.07B258.8%
CNTA$18M+0.03B176.2%
CRVS$5M+0.02B360.1%
KYMR$4M+0.01B204.3%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 12

new+$0M
0LOV.L Verastem, Inc.+$17M
new+$0M
NERV Minerva Neurosciences, Inc.new+$12M
CLDX Celldex Therapeutics, Inc.new+$10M
CRNX Crinetics Pharmaceuticals, Incnew+$8M
CRVS Corvus Pharmaceuticals, Inc.+$7M
OKUR OnKure Therapeutics, Inc.new+$6M
JBIO Jade Biosciences, Inc.new+$4M
GHRS GH Research PLCnew+$4M

Top sells this quarter · 4

RAPT RAPT Therapeutics, Inc.exit$0M
NTRA Natera, Inc.exit$13M
ATAI Atai Beckley N.Vexit$10M
AGIO Agios Pharmaceuticals, Inc.$14M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$460M17+124.17%+17.59%+106.57%-0.05B
2025-12-31$331M12+14.49%+17.72%-3.22%+0.03B
2025-09-30$259M12+41.56%+8.12%+33.44%+0.01B
2025-06-30$178M20-10.44%+10.78%-21.21%+0.01B
2025-03-31$183M14-21.55%-4.27%-17.28%+0.01B
2024-12-31$224M14