Stocks/Funds/CIK 1615982

VR Adviser, LLC

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1615982
Assets
$2.68B
+128.0% YoY
Holdings
33
Lifetime alpha vs market
-7.28% annual
Average hold time
2.0 yr
median 1.8 yr

Quarterly history

Cum return +12% vs S&P +52% · α -40% lifetimeAUM $2.7B · peak $2.7BFlow $-91M (-4%)2020-032021-032022-032023-032024-032025-032026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-2.93%
trims when stocks drop
when a holding falls −10%+
Middle response
-3.73%
baseline attrition
Rally response
-2.82%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
$715M26.7%2.8 yr
ERASErasca, Inc.$265M9.9%+1081.0%2.0 yr
ORKAOruka Therapeutics, Inc.$203M7.6%+378.1%1.8 yr
SYRESpyre Therapeutics, Inc.$186M6.9%+212.5%2.5 yr
KALVKalVista Pharmaceuticals$130M4.9%+74.4%3.5 yr
DNTHDianthus Therapeutics, I$99M3.7%+362.6%2.8 yr
DMRAGalecto, Inc.$93M3.5%0.3 yr
OCULOcular Therapeutix, Inc.$88M3.3%+15.6%2.5 yr
COGTCogent Biosciences, Inc.$77M2.9%+542.6%5.5 yr
VRDNViridian Therapeutics, I$76M2.8%+45.1%5.5 yr
SVRASavara Inc.$75M2.8%+97.1%3.3 yr
ELVNEnliven Therapeutics, In$68M2.5%+99.2%3.3 yr
ORICORIC Pharmaceuticals, In$55M2.0%+127.1%3.0 yr
VORVor Biopharma Inc.$54M2.0%+24.3%0.8 yr
MAZEMaze Therapeutics, Inc.$48M1.8%+171.1%0.8 yr

Portfolio composition (YoY)

Industry mix
Biotechnology66.8%+2.9pp$1.79B
Unknown32.5%-2.8pp$870M
Medical - Pharmaceuticals0.7%-0.2pp$20M
Country
US66.0%+6.1pp
Unknown32.5%-2.8pp
KY0.8%
CA0.7%
Top 5: 56.0% · Top 10: 72.1% · Top 25: 96.2%

Winners

TickerPrev $PnLYoY %
ERAS$22M+0.24B1081.0%
COGT$34M+0.18B542.6%
ORKA$43M+0.16B378.1%
DNTH$32M+0.11B362.6%
SYRE$43M+0.09B212.5%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 14

DMRA Galecto, Inc.new+$93M
OCUL Ocular Therapeutix, Inc.+$88M
RLMD Relmada Therapeutics, Inc.+$34M
ANL Adlai Nortye Ltd.new+$22M
VOR Vor Biopharma Inc.+$20M
DNTH Dianthus Therapeutics, Inc.+$15M
IPSC Century Therapeutics, Inc.+$14M
KRRO Korro Bio, Inc.new+$11M
ANRO Alto Neuroscience, Inc.new+$11M
MAZE Maze Therapeutics, Inc.+$48M

Top sells this quarter · 8

ELVN Enliven Therapeutics, Inc.$50M
CTMX CytomX Therapeutics, Inc.$26M
ERAS Erasca, Inc.$66M
ORIC ORIC Pharmaceuticals, Inc.$46M
UPB Upstream Bio, Inc.exit$11M
KALV KalVista Pharmaceuticals, Inc.$109M
SEPN Septerna, Inc.$3M
exit$0M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$2.68B33+203.78%+17.59%+186.19%-0.09B
2025-12-31$2.02B27+64.69%+17.72%+46.97%-0.36B
2025-09-30$1.78B33-0.08%+17.52%-17.59%-0.20B
2025-06-30$1.33B31-26.04%+14.94%-40.99%+0.02B
2025-03-31$1.18B37-44.80%+8.30%-53.10%+0.09B
2024-12-31$1.46B37-6.01%+24.89%-30.89%-0.10B
2024-09-30$1.91B38+30.39%+36.04%-5.65%+0.19B
2024-06-30$1.57B35+9.77%+24.49%-14.72%-0.18B
2024-03-31$2.10B38+43.33%+29.62%+13.71%+0.26B
2023-12-31$1.46B36+2.10%+26.18%-24.08%+0.39B
2023-09-30$950M37-36.20%+21.57%-57.77%+0.37B
2023-06-30$625M30-37.31%+19.42%-56.73%+0.07B
2023-03-31$512M25-53.21%-7.82%-45.39%-0.05B
2022-12-31$623M29-29.44%+7.56%-37.00%+0.17B
2022-09-30$648M31-9.34%-4.93%-4.41%+0.15B
2022-06-30$554M28-18.69%-16.11%-2.58%+0.05B