Stocks/Funds/CIK 1496201

SPHERA FUNDS MANAGEMENT LTD.

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1496201
Assets
$575M
+43.5% YoY
Holdings
91
Lifetime alpha vs market
-34.07% annual
Average hold time
2.8 yr
median 2.0 yr

Quarterly history

Cum return -71% vs S&P +52% · α -123% lifetimeAUM $575M · peak $1.1BFlow $59M (+12%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-1.83%
trims when stocks drop
when a holding falls −10%+
Middle response
-2.85%
baseline attrition
Rally response
-19.93%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
MLYSMineralys Therapeutics, $36M6.3%+70.6%3.3 yr
TEVATeva Pharmaceutical Indu$34M6.0%+96.0%9.5 yr
TSEMTower Semiconductor Ltd.$26M4.5%+392.1%3.8 yr
NVMINova Ltd.$23M4.0%+135.6%3.8 yr
BBIOBridgeBio Pharma, Inc.$18M3.2%+114.8%3.8 yr
BIIBBiogen Inc.$17M3.0%+34.0%7.3 yr
RAREUltragenyx Pharmaceutica$17M3.0%-42.1%4.3 yr
SNDXSyndax Pharmaceuticals, $17M2.9%+90.1%8.0 yr
COGTCogent Biosciences, Inc.$16M2.8%+542.6%2.8 yr
SNYSanofi$13M2.3%-10.4%6.5 yr
AZNAstraZeneca PLC$12M2.1%+36.2%0.3 yr
FOLDAmicus Therapeutics, Inc$9M1.5%+77.2%6.5 yr
CLBTCellebrite DI Ltd.$9M1.5%-29.1%0.5 yr
APLSApellis Pharmaceuticals,$9M1.5%+84.0%2.5 yr
PANWPalo Alto Networks, Inc.$8M1.5%-6.0%6.0 yr

Portfolio composition (YoY)

Industry mix
Biotechnology51.6%+3.7pp$297M
Drug Manufacturers - General15.9%-0.9pp$91M
Semiconductors11.0%+3.4pp$63M
Unknown6.6%-2.1pp$38M
Drug Manufacturers - Specialty & Generic6.2%+0.1pp$36M
Software - Infrastructure3.0%+1.7pp$17M
Solar1.4%+0.2pp$8M
Renewable Utilities1.3%-0.2pp$8M
Specialty Retail1.2%-0.6pp$7M
Asset Management0.8%+0.7pp$5M
Country
US63.2%+1.5pp
IL18.4%+3.1pp
Unknown6.6%-2.1pp
GB3.3%+2.1pp
CA2.6%+0.8pp
FR2.3%-2.0pp
DE1.2%+0.2pp
CH1.0%-0.4pp
Top 5: 23.9% · Top 10: 37.8% · Top 25: 59.3%

Winners

TickerPrev $PnLYoY %
TEVA$24M+0.02B96.0%
NVMI$17M+0.02B135.6%
SNDX$20M+0.02B90.1%
BBIO$13M+0.01B114.8%
COGT$2M+0.01B542.6%

Losers

TickerPrev $PnLYoY %
RARE$10M-0.00B-42.1%
SNY$17M-0.00B-10.4%

Top buys this quarter · 15

MLYS Mineralys Therapeutics, Inc.+$24M
AZN AstraZeneca PLCnew+$12M
RARE Ultragenyx Pharmaceutical Inc.+$11M
BBIO BridgeBio Pharma, Inc.+$10M
PANW Palo Alto Networks, Inc.+$6M
AAOI Applied Optoelectronics, Inc.new+$6M
XENE Xenon Pharmaceuticals Inc.+$6M
MAZE Maze Therapeutics, Inc.+$5M
CLBT Cellebrite DI Ltd.+$5M
ORA Ormat Technologies, Inc.+$4M

Top sells this quarter · 15

NICE NICE Ltd.$17M
SEDG SolarEdge Technologies, Inc.$7M
ANNX Annexon, Inc.exit$7M
ORIC ORIC Pharmaceuticals, Inc.$6M
ESLT Elbit Systems Ltd.exit$5M
DYN Dyne Therapeutics, Inc.$4M
TNGX Tango Therapeutics, Inc.$5M
AMD Advanced Micro Devices, Inc.exit$4M
CLYM Climb Bio, Inc.$4M
CYTK Cytokinetics, Incorporated$3M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$575M91+62.98%+17.59%+45.39%+0.06B
2025-12-31$474M93+27.58%+17.72%+9.86%-0.02B
2025-09-30$416M100-1.62%+17.52%-19.14%-0.06B
2025-06-30$377M100-20.02%+14.94%-34.97%-0.02B
2025-03-31$400M111-30.66%+8.30%-38.97%-0.06B
2024-12-31$536M102-9.77%+24.89%-34.66%-0.02B
2024-09-30$604M106-6.00%+36.04%-42.03%-0.02B
2024-06-30$609M108-29.97%+24.49%-54.46%+0.08B
2024-03-31$617M92-29.78%+29.62%-59.41%+0.03B
2023-12-31$533M88-63.37%+26.18%-89.55%+0.15B
2023-09-30$399M74-65.86%+21.57%-87.43%+0.05B
2023-06-30$453M75-58.03%+19.42%-77.45%+0.06B
2023-03-31$451M73-63.76%-7.82%-55.94%+0.27B
2022-12-31$314M56-10.94%+7.56%-18.50%-0.18B
2022-09-30$560M62-5.98%-4.93%-1.05%+0.07B
2022-06-30$522M47-25.14%-16.11%-9.03%+0.08B