Stocks/Funds/CIK 1839948

TCG Crossover Management, LLC

Quarterly 13F filings · Latest period 2026-03-31 · CIK 1839948
Assets
$3.50B
+376.8% YoY
Holdings
49
Lifetime alpha vs market
+19.61% annual
Average hold time
1.4 yr
median 0.8 yr

Quarterly history

Cum return +211% vs S&P +52% · α +159% lifetimeAUM $3.5B · peak $3.5BFlow $161M (+5%)2021-122022-092023-062024-032024-122025-092026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-4.71%
trims when stocks drop
when a holding falls −10%+
Middle response
-0.98%
baseline attrition
Rally response
+2.93%
adds into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
ABVXAbivax S.A.$722M20.6%+1681.6%2.5 yr
CGONCG Oncology, Inc. Common$248M7.1%+176.4%2.3 yr
TNGXTango Therapeutics, Inc.$220M6.3%+1427.0%2.3 yr
COGTCogent Biosciences, Inc.$190M5.4%+542.6%4.5 yr
CNTACentessa Pharmaceuticals$170M4.9%+176.2%2.8 yr
DNTHDianthus Therapeutics, I$141M4.0%+362.6%1.5 yr
TYRATyra Biosciences, Inc.$124M3.6%+311.8%4.5 yr
IMVTImmunovant, Inc.$111M3.2%+45.3%1.5 yr
BCRXBioCryst Pharmaceuticals$105M3.0%+26.9%0.3 yr
MIRMMirum Pharmaceuticals, I$98M2.8%+105.1%0.5 yr
VORVor Biopharma Inc.$96M2.8%+24.3%0.3 yr
SYRESpyre Therapeutics, Inc.$96M2.7%+212.5%0.8 yr
AMLXAmylyx Pharmaceuticals, $87M2.5%+292.7%1.8 yr
IRONDisc Medicine, Inc.$86M2.5%+28.8%1.8 yr
DYNDyne Therapeutics, Inc.$84M2.4%+73.3%3.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology96.0%+5.2pp$3.35B
Unknown2.9%-4.8pp$102M
Medical - Devices0.9%$33M
Medical - Pharmaceuticals0.2%$6M
Country
US69.3%-9.5pp
FR20.6%+15.5pp
GB5.3%-3.0pp
Unknown2.9%-4.8pp
CH1.2%
BE0.6%
Top 5: 44.4% · Top 10: 60.9% · Top 25: 88.3%

Winners

TickerPrev $PnLYoY %
ABVX$38M+0.64B1681.6%
COGT$42M+0.23B542.6%
TNGX$15M+0.21B1427.0%
CGON$90M+0.16B176.4%
DNTH$27M+0.10B362.6%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 15

BCRX BioCryst Pharmaceuticals, Inc.new+$105M
VOR Vor Biopharma Inc.new+$101M
MIRM Mirum Pharmaceuticals, Inc.+$92M
IMVT Immunovant, Inc.+$69M
IRON Disc Medicine, Inc.+$56M
IPSC Century Therapeutics, Inc.new+$40M
TECX Tectonic Therapeutic, Inc.new+$37M
CATX Perspective Therapeutics, Inc.new+$33M
ALXO ALX Oncology Holdings Inc.new+$26M
AGMB AgomAb Therapeutics N.V. Amerinew+$22M

Top sells this quarter · 15

ABVX Abivax S.A.$70M
LQDA Liquidia Corporation$49M
TNGX Tango Therapeutics, Inc.$113M
EYPT EyePoint Pharmaceuticals, Inc.exit$46M
AGIO Agios Pharmaceuticals, Inc.exit$40M
GPCR Structure Therapeutics Inc.$38M
COGT Cogent Biosciences, Inc.$35M
OCUL Ocular Therapeutix, Inc.$35M
URGN UroGen Pharma Ltd.$6M
MAZE Maze Therapeutics, Inc.exit$5M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$3.50B49+302.90%+17.59%+285.31%+0.16B
2025-12-31$3.02B43+158.81%+17.72%+141.09%+0.18B
2025-09-30$2.03B40+43.07%+17.52%+25.55%+0.16B
2025-06-30$876M37-25.24%+14.94%-40.18%-0.02B
2025-03-31$733M37-46.18%+8.30%-54.48%+0.01B
2024-12-31$1.02B38-10.97%+24.89%-35.86%+0.11B
2024-09-30$1.18B36+26.10%+36.04%-9.93%+0.11B
2024-06-30$960M32+8.75%+24.49%-15.74%-0.15B
2024-03-31$1.26B33+36.58%+29.62%+6.96%+0.21B
2023-12-31$902M29+7.38%+26.18%-18.80%+0.16B
2023-09-30$679M26+2.53%+21.57%-19.04%+0.09B
2023-06-30$610M22+37.58%+19.42%+18.15%+0.04B
2023-03-31$513M22+5.15%-7.82%+12.97%-0.01B
2022-12-31$567M21+4.60%+7.56%-2.96%+0.22B
2022-09-30$333M21+29.41%-4.93%+34.34%+0.03B
2022-06-30$235M22-15.74%-16.11%+0.37%+0.03B