Stocks/Funds/CIK 1799883

5AM Venture Management, LLC

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1799883
Assets
$360M
+36.2% YoY
Holdings
20
Lifetime alpha vs market
+3.56% annual
Average hold time
2.1 yr
median 2.0 yr

Quarterly history

Cum return +75% vs S&P +52% · α +23% lifetimeAUM $360M · peak $555MFlow $-76M (-24%)2019-122020-122021-122022-122023-122024-122025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-1.63%
trims when stocks drop
when a holding falls −10%+
Middle response
-3.38%
baseline attrition
Rally response
-7.32%
trims into rallies
when a holding rises +10%+

Top positions · 20

Ticker$ value% portYoYHold time
ERASErasca, Inc.$56M15.7%+1081.0%2.0 yr
TRDAEntrada Therapeutics, In$51M14.2%+39.6%4.5 yr
TYRATyra Biosciences, Inc.$39M10.9%+311.8%2.8 yr
CAMPCAMP4 Therapeutics Corpo$26M7.2%+10.3%1.5 yr
CNTACentessa Pharmaceuticals$23M6.4%+176.2%2.3 yr
PHVSPharvaris N.V.$23M6.3%+79.9%4.0 yr
MPLTMapLight Therapeutics, I$19M5.4%0.5 yr
TECXTectonic Therapeutic, In$19M5.2%+74.5%2.0 yr
CLDXCelldex Therapeutics, In$16M4.4%+74.8%3.0 yr
ARTVArtiva Biotherapeutics, $15M4.2%+114.7%1.8 yr
EYPTEyePoint Pharmaceuticals$14M3.8%+137.8%2.0 yr
$11M3.1%1.3 yr
ZNTLZentalis Pharmaceuticals$9M2.6%+47.2%3.0 yr
GHRSGH Research PLC$8M2.2%+27.5%3.0 yr
TARAProtara Therapeutics, In$7M2.0%+22.3%1.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology93.5%+11.3pp$337M
Unknown6.5%-11.3pp$23M
Country
US77.9%+12.0pp
GB7.1%+2.1pp
Unknown6.5%-11.3pp
NL6.3%+1.5pp
IE2.2%-0.2pp
Top 5: 54.4% · Top 10: 79.8% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
ERAS$7M+0.08B1081.0%
TYRA$9M+0.03B311.8%
CNTA$12M+0.02B176.2%
TRDA$40M+0.02B39.6%
PHVS$13M+0.01B79.9%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 2

ALXO ALX Oncology Holdings Inc.new+$6M
RLYB Rallybio Corporationnew+$3M

Top sells this quarter · 4

exit$0M
ERAS Erasca, Inc.$20M
ELVN Enliven Therapeutics, Inc.exit$30M
VRDN Viridian Therapeutics, Inc.exit$14M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$360M20+133.39%+17.59%+115.79%-0.08B
2025-12-31$318M21+11.43%+17.72%-6.29%-0.05B
2025-09-30$273M25-26.39%+17.52%-43.91%-0.07B
2025-06-30$260M29-33.97%+14.94%-48.91%+0.01B
2025-03-31$264M31-32.57%+8.30%-40.87%-0.01B
2024-12-31$419M31+31.68%+24.89%+6.79%-0.01B
2024-09-30$484M28+53.86%+36.04%+17.82%-0.04B
2024-06-30$447M28+15.88%+24.49%-8.61%+0.01B
2024-03-31$447M26+27.34%+29.62%-2.28%-0.04B
2023-12-31$377M25-6.05%+26.18%-32.23%+0.01B
2023-09-30$348M26-14.01%+21.57%-35.58%-0.01B
2023-06-30$401M24+10.49%+19.42%-8.94%-0.02B
2023-03-31$391M24-12.67%-7.82%-4.85%+0.04B
2022-12-31$372M21-4.51%+7.56%-12.07%-0.13B
2022-09-30$522M21+14.11%-4.93%+19.04%+0.06B
2022-06-30$404M21-15.09%-16.11%+1.02%+0.02B