Stocks/Funds/CIK 1335325

HighVista Strategies LLC

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1335325
Assets
$358M
+38.9% YoY
Holdings
155
Lifetime alpha vs market
+10.08% annual
Average hold time
2.1 yr
median 1.8 yr

Quarterly history

Cum return +123% vs S&P +52% · α +71% lifetimeAUM $358M · peak $536MFlow $-37M (-10%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-1.18%
trims when stocks drop
when a holding falls −10%+
Middle response
-6.73%
baseline attrition
Rally response
-8.69%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
DBCInvesco DB Commodity Ind$31M8.5%7.5 yr
ABVXAbivax S.A.$13M3.5%+1681.6%2.3 yr
$8M2.4%1.8 yr
COGTCogent Biosciences, Inc.$8M2.1%+542.6%3.8 yr
SYRESpyre Therapeutics, Inc.$7M2.1%+212.5%2.5 yr
PCVXVaxcyte, Inc.$7M2.0%+53.9%4.0 yr
RVMDRevolution Medicines, In$7M1.9%+175.0%4.0 yr
TERNTerns Pharmaceuticals, I$6M1.7%3.0 yr
GPCRStructure Therapeutics I$6M1.7%+178.5%2.8 yr
NUVLNuvalent, Inc.$6M1.6%+44.5%3.3 yr
IMVTImmunovant, Inc.$6M1.6%+45.3%2.8 yr
$6M1.5%2.0 yr
TYRATyra Biosciences, Inc.$5M1.4%+311.8%2.0 yr
AMLXAmylyx Pharmaceuticals, $5M1.4%+292.7%1.3 yr
AMZNAmazon.com, Inc.$5M1.3%+9.5%7.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology57.6%+28.2pp$206M
Asset Management8.5%-4.5pp$31M
Unknown8.0%+5.2pp$29M
Software - Application2.4%-3.7pp$9M
Semiconductors2.4%-0.8pp$9M
Specialty Retail2.2%-1.2pp$8M
Communication Equipment1.3%-1.6pp$5M
Engineering & Construction1.3%-0.8pp$5M
Internet Content & Information1.3%-0.3pp$5M
Computer Hardware1.2%-1.1pp$4M
Country
US77.0%-5.6pp
Unknown8.0%+5.2pp
FR4.5%+4.4pp
IE2.3%+0.6pp
NL1.8%+0.0pp
GB1.4%+0.3pp
CH1.0%+0.3pp
CA0.8%-1.9pp
Top 5: 18.6% · Top 10: 27.5% · Top 25: 45.4%

Winners

TickerPrev $PnLYoY %
COGT$2M+0.01B542.6%
ABVX$0M+0.01B1681.6%
LQDA$3M+0.00B155.9%
RVMD$3M+0.00B175.0%
PTGX$4M+0.00B117.9%

Losers

TickerPrev $PnLYoY %
MLTX$2M-0.00B-52.3%

Top buys this quarter · 15

ABVX Abivax S.A.+$5M
ORKA Oruka Therapeutics, Inc.new+$4M
TYRA Tyra Biosciences, Inc.+$4M
DFTX Definium Therapeutics, Inc.new+$4M
IVA Inventiva S.A.new+$3M
MLTX MoonLake Immunotherapeutics+$3M
NRIX Nurix Therapeutics, Inc.+$3M
ALMS Alumis Inc. Common Stocknew+$2M
EYPT EyePoint Pharmaceuticals, Inc.new+$2M
DYN Dyne Therapeutics, Inc.+$2M

Top sells this quarter · 15

APLS Apellis Pharmaceuticals, Inc.exit$6M
COGT Cogent Biosciences, Inc.$5M
AGIO Agios Pharmaceuticals, Inc.exit$5M
RVMD Revolution Medicines, Inc.$5M
VRDN Viridian Therapeutics, Inc.$5M
PTGX Protagonist Therapeutics, Inc.$4M
CYTK Cytokinetics, Incorporated$4M
GPCR Structure Therapeutics Inc.$3M
TVTX Travere Therapeutics, Inc.$3M
SNDK Sandisk Corporationexit$3M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$358M155+81.63%+17.59%+64.04%-0.04B
2025-12-31$381M144+54.90%+17.72%+37.18%-0.12B
2025-09-30$401M147+18.89%+17.52%+1.37%+0.07B
2025-06-30$271M145+11.05%+14.94%-3.89%-0.02B
2025-03-31$258M147-4.60%+8.30%-12.90%+0.02B
2024-12-31$267M136+17.69%+24.89%-7.20%-0.01B
2024-09-30$287M141+38.04%+36.04%+2.01%-0.02B
2024-06-30$265M136+24.03%+24.49%-0.46%-0.00B
2024-03-31$277M130+41.82%+29.62%+12.20%-0.02B
2023-12-31$272M125+30.38%+26.18%+4.20%+0.03B
2023-09-30$214M131+18.96%+21.57%-2.60%-0.01B
2023-06-30$219M134+18.20%+19.42%-1.23%+0.08B
2023-03-31$123M108-9.08%-7.82%-1.26%-0.05B
2022-12-31$168M105+3.41%+7.56%-4.16%-0.01B
2022-09-30$175M113+2.29%-4.93%+7.22%+0.01B
2022-06-30$166M110-14.22%-16.11%+1.89%+0.03B