Stocks/Funds/CIK 1910264

SR ONE CAPITAL MANAGEMENT, LP

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1910264
Assets
$915M
+135.2% YoY
Holdings
14
Lifetime alpha vs market
-27.44% annual
Average hold time
2.3 yr
median 2.0 yr

Quarterly history

Cum return -58% vs S&P +52% · α -110% lifetimeAUM $915M · peak $915MFlow $291M (+41%)2021-122022-092023-062024-032024-122025-092026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+1.42%
adds when stocks drop
when a holding falls −10%+
Middle response
-2.60%
baseline attrition
Rally response
+3.03%
adds into rallies
when a holding rises +10%+

Top positions · 14

Ticker$ value% portYoYHold time
ACLXArcellx, Inc.$269M29.4%4.3 yr
MANEVeradermics, Incorporate$152M16.6%0.3 yr
ZBIOZenas BioPharma, Inc.$98M10.8%+147.5%1.8 yr
CRSPCRISPR Therapeutics AG$97M10.6%+39.8%2.3 yr
DSGNDesign Therapeutics, Inc$69M7.6%+175.6%4.5 yr
ORICORIC Pharmaceuticals, In$58M6.4%+127.1%1.0 yr
ALMSAlumis Inc. Common Stock$43M4.7%+258.8%2.0 yr
MLYSMineralys Therapeutics, $42M4.6%+70.6%3.3 yr
SPRYARS Pharmaceuticals, Inc$32M3.5%-36.2%3.5 yr
ORKAOruka Therapeutics, Inc.$21M2.3%+378.1%1.8 yr
$17M1.9%1.3 yr
NKTXNkarta, Inc.$7M0.8%+14.7%4.0 yr
$5M0.6%2.0 yr
RAREUltragenyx Pharmaceutica$3M0.3%-42.1%0.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology97.6%+0.9pp$893M
Unknown2.4%-0.9pp$22M
Country
US87.0%-0.5pp
CH10.6%+1.4pp
Unknown2.4%-0.9pp
Top 5: 74.9% · Top 10: 96.5% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
ZBIO$39M+0.06B147.5%
DSGN$25M+0.04B175.6%
MLYS$50M+0.04B70.6%
ALMS$12M+0.03B258.8%
ORKA$4M+0.02B378.1%

Losers

TickerPrev $PnLYoY %
SPRY$50M-0.02B-36.2%

Top buys this quarter · 1

MANE Veradermics, Incorporatednew+$152M

Top sells this quarter · 0

No sells this quarter

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$915M14+78.85%+17.59%+61.25%+0.29B
2025-12-31$706M13+87.57%+17.72%+69.86%-0.07B
2025-09-30$691M12+25.20%+17.52%+7.68%-0.03B
2025-06-30$461M13-10.90%+14.94%-25.84%+0.01B
2025-03-31$389M12-40.25%+8.30%-48.55%+0.01B
2024-12-31$410M11-5.87%+24.89%-30.76%+0.04B
2024-09-30$499M11+62.21%+36.04%+26.17%+0.14B
2024-06-30$319M9-25.47%+24.49%-49.96%+0.04B
2024-03-31$364M6-4.04%+29.62%-33.66%+0.02B
2023-12-31$238M5-59.50%+26.18%-85.68%-0.01B
2023-09-30$195M6-79.27%+21.57%-100.84%+0.08B
2023-06-30$232M6-52.56%+19.42%-71.99%-0.04B
2023-03-31$268M6-58.87%-7.82%-51.05%+0.10B
2022-12-31$274M5-34.30%+7.56%-41.86%+0.13B
2022-09-30$219M4+17.25%-4.93%+22.18%-0.02B
2022-06-30$204M4-13.31%-16.11%+2.80%+0.03B