Stocks/Funds/CIK 1892134

Frazier Life Sciences Management, L.P.

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1892134
Assets
$3.89B
+77.6% YoY
Holdings
38
Lifetime alpha vs market
+9.38% annual
Average hold time
2.3 yr
median 2.0 yr

Quarterly history

Cum return +118% vs S&P +52% · α +66% lifetimeAUM $3.9B · peak $3.9BFlow $-53M (-1%)2022-032022-122023-092024-062025-032025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-0.51%
trims when stocks drop
when a holding falls −10%+
Middle response
-1.29%
baseline attrition
Rally response
+2.22%
adds into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
MIRMMirum Pharmaceuticals, I$709M18.3%+105.1%4.3 yr
$542M14.0%3.5 yr
ERASErasca, Inc.$399M10.3%+1081.0%2.0 yr
BBIOBridgeBio Pharma, Inc.$256M6.6%+114.8%3.3 yr
ARQTArcutis Biotherapeutics,$233M6.0%+50.6%4.3 yr
MBXMBX Biosciences, Inc. Co$199M5.1%+304.5%1.8 yr
PHATPhathom Pharmaceuticals,$139M3.6%+77.2%4.3 yr
MAZEMaze Therapeutics, Inc.$136M3.5%+171.1%1.3 yr
KRYSKrystal Biotech, Inc.$124M3.2%+43.3%4.3 yr
TRVITrevi Therapeutics, Inc.$119M3.1%+89.7%4.0 yr
PVLAPalvella Therapeutics, I$110M2.8%+345.3%1.5 yr
KALVKalVista Pharmaceuticals$100M2.6%+74.4%4.3 yr
IRONDisc Medicine, Inc.$87M2.2%+28.8%3.0 yr
CYTKCytokinetics, Incorporat$76M2.0%+64.0%1.0 yr
RVMDRevolution Medicines, In$66M1.7%+175.0%3.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology84.6%+2.7pp$3.29B
Unknown15.1%-3.0pp$587M
Drug Manufacturers - Specialty & Generic0.3%$11M
Country
US82.4%+14.7pp
Unknown15.1%-3.0pp
CN0.9%+0.3pp
IE0.6%-0.3pp
GB0.5%-11.2pp
FR0.4%
Top 5: 55.1% · Top 10: 73.5% · Top 25: 95.6%

Winners

TickerPrev $PnLYoY %
ERAS$31M+0.33B1081.0%
MIRM$306M+0.32B105.1%
BBIO$131M+0.15B114.8%
MBX$44M+0.13B304.5%
MAZE$45M+0.08B171.1%

Losers

TickerPrev $PnLYoY %
ZLAB$13M-0.01B-48.0%

Top buys this quarter · 12

MIRM Mirum Pharmaceuticals, Inc.+$82M
BCRX BioCryst Pharmaceuticals, Inc.new+$38M
ERAS Erasca, Inc.+$31M
PVLA Palvella Therapeutics, Inc.+$20M
ACRS Aclaris Therapeutics, Inc.+$17M
GLUE Monte Rosa Therapeutics, Inc.new+$16M
CYTK Cytokinetics, Incorporated+$15M
IRON Disc Medicine, Inc.+$87M
MNKD MannKind Corporation+$14M
XLO Xilio Therapeutics, Inc.new+$4M

Top sells this quarter · 15

RNAM Avidity Biosciences Incexit$0M
RAPT RAPT Therapeutics, Inc.exit$0M
exit$0M
ABVX Abivax S.A.exit$42M
RVMD Revolution Medicines, Inc.$64M
BBIO BridgeBio Pharma, Inc.$7M
TVTX Travere Therapeutics, Inc.exit$7M
DSGN Design Therapeutics, Inc.exit$6M
TRVI Trevi Therapeutics, Inc.$4M
KRYS Krystal Biotech, Inc.$120M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$3.89B38+92.18%+17.59%+74.59%-0.05B
2025-12-31$3.72B40+68.40%+17.72%+50.68%-0.57B
2025-09-30$3.34B47+18.02%+17.52%+0.50%-0.04B
2025-06-30$2.50B49+2.00%+14.94%-12.95%+0.21B
2025-03-31$2.19B47-8.60%+8.30%-16.90%-0.05B
2024-12-31$2.41B50+10.57%+24.89%-14.31%+0.16B
2024-09-30$2.50B53+43.14%+36.04%+7.10%+0.00B
2024-06-30$2.14B49+14.77%+24.49%-9.72%-0.09B
2024-03-31$2.37B50+43.66%+29.62%+14.04%+0.27B
2023-12-31$1.87B49+5.16%+26.18%-21.02%+0.12B
2023-09-30$1.50B51-4.48%+21.57%-26.05%-0.06B
2023-06-30$1.67B48+13.58%+19.42%-5.84%+0.05B
2023-03-31$1.38B49-13.70%-7.82%-5.88%+0.06B
2022-12-31$1.61B44+5.95%+7.56%-1.61%+0.23B
2022-09-30$1.30B43+11.18%-4.93%+16.11%+0.12B
2022-06-30$1.06B41-10.77%-16.11%+5.34%+0.01B