Stocks/Funds/CIK 1855655

Paradigm Biocapital Advisors LP

Quarterly 13F filings · Latest period 2026-03-31 · CIK 1855655
Assets
$4.69B
+119.3% YoY
Holdings
34
Lifetime alpha vs market
+8.17% annual
Average hold time
1.2 yr
median 0.8 yr

Quarterly history

Cum return +108% vs S&P +52% · α +56% lifetimeAUM $4.7B · peak $4.7BFlow $609M (+16%)2021-122022-092023-062024-032024-122025-092026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+9.33%
adds when stocks drop
when a holding falls −10%+
Middle response
+8.73%
steady accumulation
Rally response
+10.23%
adds into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
ACLXArcellx, Inc.$663M14.1%3.5 yr
RVMDRevolution Medicines, In$647M13.8%+175.0%2.3 yr
NUVLNuvalent, Inc.$545M11.6%+44.5%3.0 yr
PCVXVaxcyte, Inc.$279M5.9%+53.9%2.3 yr
EWTXEdgewise Therapeutics, I$232M4.9%+43.2%2.3 yr
GMABGenmab A/S$214M4.6%+37.0%0.8 yr
TARSTarsus Pharmaceuticals, $180M3.8%+36.6%2.5 yr
BLTEBelite Bio, Inc$178M3.8%+140.8%0.3 yr
ERASErasca, Inc.$168M3.6%+1081.0%2.0 yr
CNTACentessa Pharmaceuticals$142M3.0%+176.2%0.3 yr
OLMAOlema Pharmaceuticals, I$120M2.6%+296.5%3.3 yr
TERNTerns Pharmaceuticals, I$117M2.5%0.5 yr
ORKAOruka Therapeutics, Inc.$114M2.4%+378.1%1.0 yr
$113M2.4%2.3 yr
SYRESpyre Therapeutics, Inc.$99M2.1%+212.5%1.8 yr

Portfolio composition (YoY)

Industry mix
Biotechnology97.2%+7.3pp$4.56B
Unknown2.8%+1.1pp$132M
Country
US87.3%-1.2pp
DK4.6%
GB3.0%
Unknown2.8%+1.1pp
FR2.3%
Top 5: 50.5% · Top 10: 69.3% · Top 25: 95.8%

Winners

TickerPrev $PnLYoY %
RVMD$218M+0.38B175.0%
NUVL$374M+0.17B44.5%
ERAS$15M+0.16B1081.0%
OLMA$25M+0.08B296.5%
SYRE$34M+0.07B212.5%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 15

BLTE Belite Bio, Incnew+$178M
CNTA Centessa Pharmaceuticals plcnew+$142M
MAZE Maze Therapeutics, Inc.new+$82M
TYRA Tyra Biosciences, Inc.new+$79M
MIRM Mirum Pharmaceuticals, Inc.new+$58M
PCVX Vaxcyte, Inc.+$42M
CYTK Cytokinetics, Incorporated+$41M
VRDN Viridian Therapeutics, Inc.+$33M
MANE Veradermics, Incorporatednew+$33M
ORKA Oruka Therapeutics, Inc.+$30M

Top sells this quarter · 11

SRRK Scholar Rock Holding Corporati$90M
CRNX Crinetics Pharmaceuticals, Incexit$80M
ABVX Abivax S.A.$72M
ERAS Erasca, Inc.$53M
BBIO BridgeBio Pharma, Inc.exit$51M
URGN UroGen Pharma Ltd.$50M
OCUL Ocular Therapeutix, Inc.exit$25M
BBOT BridgeBio Oncology Therapeutic$12M
ORIC ORIC Pharmaceuticals, Inc.$20M
EYPT EyePoint Pharmaceuticals, Inc.$7M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$4.69B34+80.47%+17.59%+62.88%+0.61B
2025-12-31$3.73B29+34.95%+17.72%+17.23%-0.62B
2025-09-30$3.38B33-1.86%+17.52%-19.38%+0.30B
2025-06-30$2.34B28-12.74%+14.94%-27.68%+0.26B
2025-03-31$2.14B26-16.51%+8.30%-24.82%-0.21B
2024-12-31$2.87B28+5.99%+24.89%-18.90%+0.20B
2024-09-30$2.86B31+34.13%+36.04%-1.91%-0.20B
2024-06-30$2.61B35+10.92%+24.49%-13.57%-0.04B
2024-03-31$2.84B34+28.52%+29.62%-1.10%+0.63B
2023-12-31$2.13B29+11.87%+26.18%-14.31%+0.40B
2023-09-30$1.47B29+10.48%+21.57%-11.08%+0.27B
2023-06-30$1.24B29+22.24%+19.42%+2.82%+0.10B
2023-03-31$1.06B25+7.60%-7.82%+15.41%+0.29B
2022-12-31$852M23+17.08%+7.56%+9.52%+0.02B
2022-09-30$710M27+7.00%-4.93%+11.93%+0.17B
2022-06-30$502M23-4.85%-16.11%+11.26%+0.14B