Stocks/Funds/CIK 1791827

Avidity Partners Management LP

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1791827
Assets
$505M
+6.0% YoY
Holdings
52
Lifetime alpha vs market
-28.79% annual
Average hold time
1.6 yr
median 1.0 yr

Quarterly history

Cum return -61% vs S&P +52% · α -113% lifetimeAUM $505M · peak $4.7BFlow $69M (+20%)2019-122020-122021-122022-122023-122024-122025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-21.09%
trims when stocks drop
when a holding falls −10%+
Middle response
-25.43%
baseline attrition
Rally response
-22.55%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
DNTHDianthus Therapeutics, I$177M34.9%+362.6%2.8 yr
CGONCG Oncology, Inc. Common$87M17.3%+176.4%2.3 yr
ORKAOruka Therapeutics, Inc.$37M7.4%+378.1%1.8 yr
CATXPerspective Therapeutics$25M5.0%+95.8%2.0 yr
JBIOJade Biosciences, Inc.$20M3.9%1.0 yr
ELVNEnliven Therapeutics, In$16M3.1%+99.2%1.3 yr
TEVATeva Pharmaceutical Indu$14M2.7%+96.0%1.3 yr
CNTXContext Therapeutics Inc$13M2.6%+328.1%2.0 yr
RGENRepligen Corporation$9M1.8%-7.4%1.0 yr
PVLAPalvella Therapeutics, I$9M1.7%+345.3%0.5 yr
MDTMedtronic plc$9M1.7%-1.3%2.0 yr
VIRVir Biotechnology, Inc.$9M1.7%+38.3%2.5 yr
AKTSAktis Oncology, Inc.$8M1.7%0.3 yr
$7M1.5%2.3 yr
HUMHumana Inc.$6M1.2%-33.8%3.0 yr

Portfolio composition (YoY)

Industry mix
Biotechnology77.8%+29.8pp$393M
Medical - Devices9.3%-5.2pp$47M
Drug Manufacturers - Specialty & Generic3.1%+1.3pp$15M
Unknown2.3%-1.0pp$12M
Medical - Healthcare Plans1.8%-8.2pp$9M
Medical - Instruments & Supplies1.8%+0.3pp$9M
Medical - Diagnostics & Research1.0%-9.2pp$5M
Medical - Care Facilities0.8%-1.2pp$4M
Drug Manufacturers - General0.6%-1.1pp$3M
Medical - Pharmaceuticals0.4%$2M
Country
US91.6%+2.6pp
IL2.7%+1.1pp
Unknown2.3%-1.0pp
IE2.1%-0.0pp
CA0.4%-1.2pp
DK0.3%
FR0.2%
CH0.2%
Top 5: 68.5% · Top 10: 80.4% · Top 25: 94.3%

Winners

TickerPrev $PnLYoY %
DNTH$31M+0.11B362.6%
CGON$24M+0.04B176.4%
CNTX$5M+0.02B328.1%
ORKA$4M+0.01B378.1%
TEVA$7M+0.01B96.0%

Losers

TickerPrev $PnLYoY %
BSX$34M-0.01B-37.8%
HUM$21M-0.01B-33.8%
DXCM$12M-0.00B-8.0%
SCYX$1M-0.00B-3.7%

Top buys this quarter · 15

CATX Perspective Therapeutics, Inc.+$12M
ELVN Enliven Therapeutics, Inc.+$10M
AKTS Aktis Oncology, Inc.new+$8M
PVLA Palvella Therapeutics, Inc.+$6M
ORKA Oruka Therapeutics, Inc.+$5M
RGEN Repligen Corporation+$3M
PODD Insulet Corporationnew+$2M
KPTI Karyopharm Therapeutics Inc.+$2M
CRVS Corvus Pharmaceuticals, Inc.new+$2M
HIMS Hims & Hers Health, Inc.new+$2M

Top sells this quarter · 15

ABT Abbott Laboratories$35M
GILD Gilead Sciences, Inc.$33M
RVMD Revolution Medicines, Inc.$21M
GPCR Structure Therapeutics Inc.$19M
CGON CG Oncology, Inc. Common stock$61M
BBIO BridgeBio Pharma, Inc.$10M
MCK McKesson Corporationexit$8M
CRL Charles River Laboratories Int$8M
DXCM DexCom, Inc.$8M
ALNY Alnylam Pharmaceuticals, Inc.exit$7M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$505M52+58.86%+17.59%+41.27%+0.07B
2025-12-31$344M38+9.99%+17.72%-7.73%-0.13B
2025-09-30$438M42-16.29%+17.52%-33.80%-0.12B
2025-06-30$493M54-18.13%+14.94%-33.07%+0.00B
2025-03-31$477M62-27.83%+8.30%-36.13%-0.39B
2024-12-31$987M60-12.51%+24.89%-37.39%-0.59B
2024-09-30$1.92B80+7.98%+36.04%-28.06%-0.66B
2024-06-30$2.32B84-24.55%+24.49%-49.04%-0.22B
2024-03-31$2.81B87-19.70%+29.62%-49.33%+0.03B
2023-12-31$2.61B72-49.41%+26.18%-75.59%+0.10B
2023-09-30$2.48B83-53.56%+21.57%-75.12%+0.26B
2023-06-30$2.86B93-38.78%+19.42%-58.20%-0.03B
2023-03-31$3.01B83-57.49%-7.82%-49.68%+0.14B
2022-12-31$4.28B84-7.09%+7.56%-14.65%+0.01B
2022-09-30$4.60B95+2.22%-4.93%+7.15%+0.14B
2022-06-30$4.36B82-33.28%-16.11%-17.17%+1.37B