Stocks/Funds/CIK 1744967

Samsara BioCapital, LLC

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1744967
Assets
$1.03B
+83.5% YoY
Holdings
22
Lifetime alpha vs market
-14.64% annual
Average hold time
1.8 yr
median 1.5 yr

Quarterly history

Cum return -19% vs S&P +52% · α -71% lifetimeAUM $1.0B · peak $1.0BFlow $95M (+10%)2018-122020-032021-062022-092023-122025-032026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-0.86%
trims when stocks drop
when a holding falls −10%+
Middle response
-1.99%
baseline attrition
Rally response
-5.37%
trims into rallies
when a holding rises +10%+

Top positions · 22

Ticker$ value% portYoYHold time
SRRKScholar Rock Holding Cor$339M32.9%+52.9%4.3 yr
MLYSMineralys Therapeutics, $159M15.5%+70.6%3.3 yr
ALMSAlumis Inc. Common Stock$140M13.6%+258.8%1.8 yr
SEPNSepterna, Inc.$76M7.4%+315.0%1.5 yr
KLRSKalaris Therapeutics Inc$75M7.3%-28.1%1.3 yr
SGPSpyGlass Pharma, Inc. Co$55M5.3%0.3 yr
NGNENeurogene Inc.$35M3.4%+72.2%2.5 yr
IVAInventiva S.A.$29M2.8%+88.8%0.5 yr
$26M2.6%0.5 yr
JBIOJade Biosciences, Inc.$14M1.3%1.0 yr
$12M1.2%2.5 yr
AQSTAquestive Therapeutics, $10M1.0%+43.1%0.8 yr
XFORX4 Pharmaceuticals, Inc.$8M0.7%-41.7%0.5 yr
NKTXNkarta, Inc.$7M0.7%+14.7%5.8 yr
ACLXArcellx, Inc.$7M0.7%4.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology95.3%-0.6pp$980M
Unknown3.7%-0.4pp$38M
Drug Manufacturers - Specialty & Generic1.0%$10M
Country
US92.3%-3.2pp
Unknown3.7%-0.4pp
FR3.4%+2.9pp
BE0.6%
Top 5: 76.6% · Top 10: 92.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
SRRK$180M+0.10B52.9%
PVLA$19M+0.07B345.3%
MLYS$90M+0.06B70.6%
SEPN$18M+0.06B315.0%
ALMS$20M+0.05B258.8%

Losers

TickerPrev $PnLYoY %
KLRS$92M-0.03B-28.1%
GOSS$7M-0.00B-70.1%

Top buys this quarter · 5

SGP SpyGlass Pharma, Inc. Common Snew+$55M
ALMS Alumis Inc. Common Stock+$13M
AGMB AgomAb Therapeutics N.V. Amerinew+$6M
CHRS Coherus Oncology, Inc.new+$6M
+$0M

Top sells this quarter · 5

PVLA Palvella Therapeutics, Inc.$8M
ABVX Abivax S.A.$2M
CTNM Contineum Therapeutics, Inc. Cexit$1M
XFOR X4 Pharmaceuticals, Inc.$1M
NUVB-WT Nuvation Bio Inc.exit$0M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$1.03B22+77.07%+17.59%+59.48%+0.10B
2025-12-31$969M21+30.31%+17.72%+12.59%+0.06B
2025-09-30$766M27+48.90%+17.52%+31.38%-0.04B
2025-06-30$489M29-4.93%+14.94%-19.87%-0.03B
2025-03-31$561M37-33.58%+8.30%-41.89%+0.04B
2024-12-31$729M43+21.93%+24.89%-2.96%+0.02B
2024-09-30$520M42+31.40%+36.04%-4.64%+0.02B
2024-06-30$478M40-3.55%+24.49%-28.04%+0.06B
2024-03-31$646M39+42.35%+29.62%+12.73%-0.19B
2023-12-31$643M41-16.38%+26.18%-42.56%+0.16B
2023-09-30$327M41-59.95%+21.57%-81.52%-0.11B
2023-06-30$570M47-44.25%+19.42%-63.67%+0.10B
2023-03-31$484M56-51.75%-7.82%-43.93%+0.13B
2022-12-31$464M54-29.72%+7.56%-37.28%+0.16B
2022-09-30$428M55+7.88%-4.93%+12.81%+0.03B
2022-06-30$374M56-16.77%-16.11%-0.66%+0.04B