Stocks/Funds/CIK 1389933

DAFNA Capital Management LLC

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1389933
Assets
$434M
+24.6% YoY
Holdings
82
Lifetime alpha vs market
-19.41% annual
Average hold time
3.6 yr
median 2.3 yr

Quarterly history

Cum return -36% vs S&P +52% · α -88% lifetimeAUM $434M · peak $473MFlow $-11M (-3%)2016-032017-092019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+3.04%
adds when stocks drop
when a holding falls −10%+
Middle response
+0.29%
steady accumulation
Rally response
-5.97%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
RVMDRevolution Medicines, In$56M13.0%+175.0%5.5 yr
XBIState Street SPDR S&P Bi$41M9.4%4.3 yr
STXSStereotaxis, Inc.$25M5.8%+4.5%10.3 yr
DAWNDay One Biopharmaceutica$21M4.8%+170.4%3.0 yr
ATRCAtriCure, Inc.$17M3.9%-11.6%10.3 yr
IDYAIDEAYA Biosciences, Inc.$16M3.7%+103.4%5.8 yr
XENEXenon Pharmaceuticals In$15M3.4%+73.3%10.3 yr
CYTKCytokinetics, Incorporat$14M3.3%+64.0%7.5 yr
CMPSCOMPASS Pathways plc$13M3.1%+93.4%3.5 yr
NKTRNektar Therapeutics$12M2.7%1.0 yr
IBBiShares Biotechnology ET$10M2.4%9.8 yr
RCUSArcus Biosciences, Inc.$10M2.2%+175.2%6.5 yr
NBIXNeurocrine Biosciences, $9M2.1%+19.1%10.0 yr
LRMRLarimar Therapeutics, In$9M2.1%+109.3%6.0 yr
BCAXBicara Therapeutics Inc.$8M1.9%+52.6%1.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology61.6%+4.5pp$267M
Asset Management11.8%-1.4pp$51M
Medical - Instruments & Supplies9.7%-2.7pp$42M
Medical - Devices9.1%-1.4pp$39M
Unknown4.1%-2.0pp$18M
Medical - Care Facilities3.1%+2.5pp$13M
Drug Manufacturers - Specialty & Generic0.6%+0.5pp$3M
Country
US84.9%+4.0pp
CA4.3%+1.7pp
Unknown4.1%-2.0pp
GB3.2%+2.2pp
IE1.1%+0.2pp
BE0.9%-0.0pp
DE0.7%-0.1pp
NL0.6%-5.6pp
Top 5: 37.0% · Top 10: 53.1% · Top 25: 77.9%

Winners

TickerPrev $PnLYoY %
RVMD$23M+0.04B175.0%
STOK$3M+0.01B389.6%
CYTK$16M+0.01B64.0%
IDYA$10M+0.01B103.4%
AXGN$13M+0.01B79.1%

Losers

TickerPrev $PnLYoY %
ATRC$19M-0.00B-11.6%
INGN$3M-0.00B-13.3%
DXCM$4M-0.00B-8.0%

Top buys this quarter · 15

CMPS COMPASS Pathways plc+$9M
NKTR Nektar Therapeutics+$6M
LRMR Larimar Therapeutics, Inc.+$5M
BCAX Bicara Therapeutics Inc. Commo+$3M
FULC Fulcrum Therapeutics, Inc.new+$2M
KIDS OrthoPediatrics Corp.new+$2M
CTMX CytomX Therapeutics, Inc.+$1M
MAZE Maze Therapeutics, Inc.new+$1M
RARE Ultragenyx Pharmaceutical Inc.+$1M
SCYX SCYNEXIS, Inc.+$1M

Top sells this quarter · 15

CYTK Cytokinetics, Incorporated$10M
AXGN AxoGen, Inc.$8M
ERAS Erasca, Inc.exit$4M
RVMD Revolution Medicines, Inc.$48M
XENE Xenon Pharmaceuticals Inc.$13M
KALV KalVista Pharmaceuticals, Inc.$2M
EWTX Edgewise Therapeutics, Inc.$1M
SNDX Syndax Pharmaceuticals, Inc.$1M
IDYA IDEAYA Biosciences, Inc.$1M
ANNX Annexon, Inc.$1M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$434M82+68.90%+17.59%+51.30%-0.01B
2025-12-31$425M76+31.69%+17.72%+13.97%-0.05B
2025-09-30$399M74-2.76%+17.52%-20.28%-0.08B
2025-06-30$357M75-21.19%+14.94%-36.13%-0.00B
2025-03-31$348M82-38.06%+8.30%-46.36%+0.03B
2024-12-31$389M81-7.06%+24.89%-31.95%+0.02B
2024-09-30$419M83+44.52%+36.04%+8.48%-0.03B
2024-06-30$414M82+14.79%+24.49%-9.70%+0.06B
2024-03-31$435M71+20.53%+29.62%-9.09%-0.07B
2023-12-31$413M75-18.50%+26.18%-44.68%-0.02B
2023-09-30$318M74-50.41%+21.57%-71.98%+0.01B
2023-06-30$362M72-41.46%+19.42%-60.89%+0.08B
2023-03-31$334M72-49.10%-7.82%-41.28%+0.04B
2022-12-31$355M79-17.38%+7.56%-24.94%+0.05B
2022-09-30$369M85+0.94%-4.93%+5.87%+0.00B
2022-06-30$362M88-26.32%-16.11%-10.21%+0.08B