Stocks/Funds/CIK 1281446

GREAT POINT PARTNERS LLC

Quarterly 13F filings · Latest period 2026-03-31 · CIK 1281446
Assets
$408M
+121.9% YoY
Holdings
39
Lifetime alpha vs market
-16.89% annual
Average hold time
0.9 yr
median 0.5 yr

Quarterly history

Cum return -27% vs S&P +52% · α -80% lifetimeAUM $408M · peak $1.2BFlow $48M (+15%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-10.13%
trims when stocks drop
when a holding falls −10%+
Middle response
-5.81%
baseline attrition
Rally response
-11.20%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
$31M7.7%1.5 yr
VORVor Biopharma Inc.$31M7.6%+24.3%0.5 yr
$25M6.1%3.0 yr
AMLXAmylyx Pharmaceuticals, $24M6.0%+292.7%2.0 yr
NKTRNektar Therapeutics$23M5.6%0.8 yr
SLGLSol-Gel Technologies Ltd$22M5.3%0.3 yr
ALMSAlumis Inc. Common Stock$19M4.6%+258.8%0.3 yr
$16M3.9%0.3 yr
ANNXAnnexon, Inc.$14M3.4%+187.0%0.3 yr
KALVKalVista Pharmaceuticals$14M3.3%+74.4%3.3 yr
IMVTImmunovant, Inc.$14M3.3%+45.3%1.3 yr
JBIOJade Biosciences, Inc.$14M3.3%1.0 yr
CTNMContineum Therapeutics, $10M2.6%+87.1%0.5 yr
ZBIOZenas BioPharma, Inc.$10M2.5%+147.5%0.3 yr
NGNENeurogene Inc.$10M2.5%+72.2%2.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology73.0%-4.4pp$298M
Unknown24.3%+12.1pp$99M
Drug Manufacturers - Specialty & Generic1.7%-8.7pp$7M
Medical - Pharmaceuticals1.0%$4M
Country
US65.8%-0.5pp
Unknown24.3%+12.1pp
IL5.3%
CH2.3%
GB1.3%-3.7pp
NL0.6%-4.9pp
IE0.4%
Top 5: 33.0% · Top 10: 53.6% · Top 25: 87.2%

Winners

TickerPrev $PnLYoY %
AMLX$6M+0.02B292.7%
CNTX$3M+0.01B328.1%
KALV$12M+0.01B74.4%
NGNE$6M+0.00B72.2%
IMVT$6M+0.00B45.3%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 15

SLGL Sol-Gel Technologies Ltd.new+$22M
ALMS Alumis Inc. Common Stocknew+$19M
ANNX Annexon, Inc.new+$14M
ZBIO Zenas BioPharma, Inc.new+$10M
VERA Vera Therapeutics, Inc.new+$8M
NKTR Nektar Therapeutics+$8M
LBRX LB Pharmaceuticals Inc Common new+$7M
CMPX Compass Therapeutics, Inc.new+$7M
SCYX SCYNEXIS, Inc.new+$7M
VOR Vor Biopharma Inc.+$7M

Top sells this quarter · 13

DNTH Dianthus Therapeutics, Inc.exit$29M
ALKS Alkermes plc$29M
IRON Disc Medicine, Inc.exit$16M
CNTX Context Therapeutics Inc.$6M
RARE Ultragenyx Pharmaceutical Inc.exit$6M
FULC Fulcrum Therapeutics, Inc.exit$6M
IMVT Immunovant, Inc.$5M
CGEM Cullinan Therapeutics, Inc.$5M
UPB Upstream Bio, Inc.exit$3M
SANA Sana Biotechnology, Inc.exit$2M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$408M39+95.01%+17.59%+77.42%+0.05B
2025-12-31$308M29+17.12%+17.72%-0.60%+0.10B
2025-09-30$240M28+3.50%+17.52%-14.01%-0.05B
2025-06-30$154M26-46.18%+14.94%-61.12%-0.03B
2025-03-31$184M31-54.45%+8.30%-62.75%+0.04B
2024-12-31$212M26-29.10%+24.89%-53.98%-0.04B
2024-09-30$331M29+10.92%+36.04%-25.12%-0.16B
2024-06-30$505M32+0.48%+24.49%-24.01%-0.03B
2024-03-31$621M34+3.71%+29.62%-25.91%-0.01B
2023-12-31$580M33-21.15%+26.18%-47.33%-0.05B
2023-09-30$522M38-32.42%+21.57%-53.98%+0.08B
2023-06-30$499M36-24.62%+19.42%-44.05%+0.05B
2023-03-31$506M42-21.18%-7.82%-13.37%+0.10B
2022-12-31$484M40+2.76%+7.56%-4.80%+0.06B
2022-09-30$415M40-1.02%-4.93%+3.91%+0.03B
2022-06-30$388M33-6.73%-16.11%+9.38%+0.00B