Stocks/Funds/CIK 1232621

TANG CAPITAL MANAGEMENT LLC

long-term holder
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1232621
Assets
$1.93B
+7.0% YoY
Holdings
50
Lifetime alpha vs market
-20.55% annual
Average hold time
2.6 yr
median 2.3 yr

Quarterly history

Cum return -39% vs S&P +52% · α -92% lifetimeAUM $1.9B · peak $2.6BFlow $-96M (-5%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+2.56%
adds when stocks drop
when a holding falls −10%+
Middle response
+1.65%
steady accumulation
Rally response
-0.22%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
AUPHAurinia Pharmaceuticals $181M9.4%+84.3%3.5 yr
CELCCelcuity Inc.$120M6.2%+1029.0%0.8 yr
MIRMMirum Pharmaceuticals, I$114M5.9%+105.1%4.0 yr
GLPGGalapagos N.V.$114M5.9%+19.4%3.8 yr
SPYState Street SPDR S&P 50$109M5.7%+17.6%0.5 yr
$109M5.6%2.0 yr
CAPRCapricor Therapeutics, I$103M5.4%+220.3%0.8 yr
PTCTPTC Therapeutics, Inc.$102M5.3%+33.7%2.5 yr
SYRESpyre Therapeutics, Inc.$95M5.0%+212.5%1.3 yr
KALVKalVista Pharmaceuticals$92M4.8%+74.4%4.3 yr
CMPXCompass Therapeutics, In$89M4.6%+178.4%1.8 yr
TARSTarsus Pharmaceuticals, $83M4.3%+36.6%4.3 yr
IMCRImmunocore Holdings plc$80M4.1%+1.6%4.3 yr
ANABAnaptysBio, Inc.$74M3.8%+198.4%6.5 yr
CORTCorcept Therapeutics Inc$60M3.1%-64.7%0.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology82.5%+11.3pp$1.59B
Unknown7.0%+0.0pp$135M
Asset Management5.7%$109M
Drug Manufacturers - Specialty & Generic3.3%-8.4pp$64M
Medical - Care Facilities1.1%+0.9pp$22M
Drug Manufacturers - General0.3%-1.8pp$6M
Country
US70.0%-1.8pp
CA9.4%+3.1pp
Unknown7.0%+0.0pp
BE5.9%+0.4pp
GB5.3%+1.0pp
DE2.2%+0.8pp
SG0.2%
Top 5: 33.1% · Top 10: 59.2% · Top 25: 93.8%

Winners

TickerPrev $PnLYoY %
SYRE$33M+0.07B212.5%
AUPH$81M+0.07B84.3%
MIRM$56M+0.06B105.1%
TARS$126M+0.05B36.6%
KALV$57M+0.04B74.4%

Losers

TickerPrev $PnLYoY %
DERM$11M-0.00B-20.5%
JANX$4M-0.00B-48.5%
BNTX$25M-0.00B-2.4%
PLRX$8M-0.00B-6.7%

Top buys this quarter · 10

SPY State Street SPDR S&P 500 ETF +$90M
CORT Corcept Therapeutics Incorpora+$54M
CAPR Capricor Therapeutics, Inc.+$52M
ANIP ANI Pharmaceuticals, Inc.+$17M
AUPH Aurinia Pharmaceuticals Inc.+$13M
CMPS COMPASS Pathways plc+$10M
AGIO Agios Pharmaceuticals, Inc.new+$3M
PGEN Precigen, Inc.+$3M
IMCR Immunocore Holdings plc+$80M
+$0M

Top sells this quarter · 15

VTYX Ventyx Biosciences, Inc.exit$39M
VRTX Vertex Pharmaceuticals Incorpoexit$36M
MRNA Moderna, Inc.$30M
NVDA NVIDIA Corporationexit$22M
TVTX Travere Therapeutics, Inc.exit$21M
IBRX ImmunityBio, Inc.exit$18M
GSK GSK plcexit$17M
PCVX Vaxcyte, Inc.exit$16M
META Meta Platforms, Inc.exit$13M
BMY Bristol-Myers Squibb Companyexit$12M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$1.93B50+50.43%+17.59%+32.84%-0.10B
2025-12-31$2.01B74+30.05%+17.72%+12.33%-1.06B
2025-09-30$2.57B193-6.57%+17.52%-24.08%+0.15B
2025-06-30$1.96B199-17.65%+14.94%-32.59%+0.14B
2025-03-31$1.80B201-38.31%+8.30%-46.61%+0.49B
2024-12-31$1.50B182-16.14%+24.89%-41.02%+0.31B
2024-09-30$1.39B153+4.88%+36.04%-31.16%+0.33B
2024-06-30$972M126-15.96%+24.49%-40.45%+0.24B
2024-03-31$960M99-6.07%+29.62%-35.69%-0.31B
2023-12-31$1.08B122-35.22%+26.18%-61.39%+0.32B
2023-09-30$704M105-43.39%+21.57%-64.96%+0.11B
2023-06-30$676M98-29.73%+19.42%-49.15%+0.11B
2023-03-31$668M102-30.43%-7.82%-22.61%+0.11B
2022-12-31$685M88-6.00%+7.56%-13.56%-0.07B
2022-09-30$805M94+8.39%-4.93%+13.32%+0.09B
2022-06-30$659M67-16.10%-16.11%+0.01%+0.24B