Stocks/Funds/CIK 1977548

Checkpoint Capital L.P.

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1977548
Assets
$279M
+52.9% YoY
Holdings
8
Lifetime alpha vs market
+12.42% annual
Average hold time
1.7 yr
median 1.8 yr

Quarterly history

Cum return +83% vs S&P +41% · α +42% lifetimeAUM $279M · peak $316MFlow $-13M (-4%)2023-122024-062024-122025-062025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+20.94%
adds when stocks drop
when a holding falls −10%+
Middle response
+17.10%
steady accumulation
Rally response
-17.90%
trims into rallies
when a holding rises +10%+

Top positions · 8

Ticker$ value% portYoYHold time
ARGXargenx SE$112M40.1%+23.4%2.5 yr
RYTMRhythm Pharmaceuticals, $107M38.3%+64.2%2.5 yr
RVMDRevolution Medicines, In$26M9.2%+175.0%1.5 yr
IRONDisc Medicine, Inc.$18M6.6%+28.8%2.0 yr
CYTKCytokinetics, Incorporat$12M4.3%+64.0%2.0 yr
SEPNSepterna, Inc.$2M0.9%+315.0%1.0 yr
CRNXCrinetics Pharmaceutical$1M0.5%+8.3%0.5 yr
TRVITrevi Therapeutics, Inc.$1M0.2%+89.7%1.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology100.0%+6.9pp$279M
Country
US59.9%+4.2pp
NL40.1%+2.8pp
Top 5: 98.4% · Top 10: 100.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
RYTM$48M+0.03B64.2%
RVMD$14M+0.02B175.0%
ARGX$68M+0.02B23.4%
SEPN$5M+0.02B315.0%
IRON$12M+0.00B28.8%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 3

RYTM Rhythm Pharmaceuticals, Inc.+$20M
ARGX argenx SE+$112M
CYTK Cytokinetics, Incorporated+$1M

Top sells this quarter · 6

CORT Corcept Therapeutics Incorporaexit$16M
TRVI Trevi Therapeutics, Inc.$12M
IRON Disc Medicine, Inc.$11M
RVMD Revolution Medicines, Inc.$10M
CRNX Crinetics Pharmaceuticals, Inc$8M
SEPN Septerna, Inc.$4M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$279M8+57.62%+17.59%+40.03%-0.01B
2025-12-31$316M6+69.52%+17.72%+51.80%-0.01B
2025-09-30$298M10+49.75%+17.52%+32.23%-0.01B
2025-06-30$215M8+28.48%+14.94%+13.54%+0.02B
2025-03-31$182M14+16.05%+8.30%+7.75%-0.01B
2024-12-31$196M16+17.00%+24.89%-7.88%+0.00B
2024-09-30$202M16+23.47%+5.75%+17.72%-0.00B
2024-06-30$166M16-1.62%+4.38%-6.00%+0.02B
2024-03-31$150M17+0.02%+10.39%-10.37%+0.01B
2023-12-31$143M17