Stocks/Funds/CIK 1577524

Sarissa Capital Management LP

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1577524
Assets
$158M
+1.9% YoY
Holdings
9
Lifetime alpha vs market
-11.02% annual
Average hold time
3.1 yr
median 1.8 yr

Quarterly history

Cum return -5% vs S&P +52% · α -57% lifetimeAUM $158M · peak $1.3BFlow $-78M (-35%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-0.66%
trims when stocks drop
when a holding falls −10%+
Middle response
-7.31%
baseline attrition
Rally response
-3.67%
trims into rallies
when a holding rises +10%+

Top positions · 9

Ticker$ value% portYoYHold time
INVAInnoviva, Inc.$50M31.5%+28.5%9.8 yr
IRWDIronwood Pharmaceuticals$32M20.5%+138.8%8.5 yr
AMRNAmarin Corporation plc$24M15.4%+61.4%1.0 yr
NBIXNeurocrine Biosciences, $15M9.7%+19.1%3.0 yr
CYTKCytokinetics, Incorporat$15M9.6%+64.0%2.3 yr
LNTHLantheus Holdings, Inc.$13M8.0%-22.3%1.8 yr
$5M3.0%0.5 yr
REGNRegeneron Pharmaceutical$3M2.1%+22.5%0.8 yr
VORVor Biopharma Inc.$0M0.3%+24.3%0.8 yr

Portfolio composition (YoY)

Industry mix
Biotechnology68.5%-2.2pp$108M
Drug Manufacturers - Specialty & Generic28.5%+6.6pp$45M
Unknown3.0%-4.4pp$5M
Country
US81.6%-10.9pp
IE15.4%
Unknown3.0%-4.4pp
Top 5: 86.6% · Top 10: 100.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
IRWD$24M+0.03B138.8%
CYTK$24M+0.02B64.0%
INVA$51M+0.01B28.5%
NBIX$34M+0.01B19.1%
LNTH$10M-0.00B-22.3%

Losers

TickerPrev $PnLYoY %
LNTH$10M-0.00B-22.3%

Top buys this quarter · 1

+$5M

Top sells this quarter · 5

NBIX Neurocrine Biosciences, Inc.$25M
IRWD Ironwood Pharmaceuticals, Inc.$24M
INVA Innoviva, Inc.$16M
CYTK Cytokinetics, Incorporated$11M
LNTH Lantheus Holdings, Inc.$12M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$158M9+43.36%+17.59%+25.76%-0.08B
2025-12-31$223M9+12.33%+17.72%-5.38%-0.00B
2025-09-30$180M8-9.52%+17.52%-27.03%+0.01B
2025-06-30$154M7-24.45%+14.94%-39.39%+0.00B
2025-03-31$155M7-26.14%+8.30%-34.44%-0.11B
2024-12-31$323M8-22.76%+24.89%-47.65%-0.08B
2024-09-30$402M10-15.70%+36.04%-51.74%-0.15B
2024-06-30$592M10-17.07%+24.49%-41.56%+0.05B
2024-03-31$572M10-8.75%+29.62%-38.37%+0.01B
2023-12-31$649M9+1.55%+26.18%-24.63%-0.16B
2023-09-30$742M11+8.16%+21.57%-13.40%-0.18B
2023-06-30$1.00B11+4.42%+19.42%-15.00%+0.18B
2023-03-31$782M11-1.28%-7.82%+6.53%-0.03B
2022-12-31$840M11+15.92%+7.56%+8.36%-0.19B
2022-09-30$885M11-10.91%-4.93%-5.98%-0.00B
2022-06-30$993M11-0.71%-16.11%+15.40%-0.06B