Stocks/Funds/CIK 1482416

Sio Capital Management, LLC

Quarterly 13F filings · Latest period 2026-03-31 · CIK 1482416
Assets
$694M
+110.1% YoY
Holdings
73
Lifetime alpha vs market
-4.71% annual
Average hold time
1.5 yr
median 1.0 yr

Quarterly history

Cum return +25% vs S&P +52% · α -27% lifetimeAUM $694M · peak $694MFlow $78M (+13%)2016-062017-122019-062020-122022-062023-122025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+6.30%
adds when stocks drop
when a holding falls −10%+
Middle response
-2.38%
baseline attrition
Rally response
-18.29%
trims into rallies
when a holding rises +10%+

Top positions · 30

Ticker$ value% portYoYHold time
MMSMaximus, Inc.$49M7.1%-4.5%1.8 yr
WAYWaystar Holding Corp.$40M5.7%-35.5%0.5 yr
ICLRICON Public Limited Comp$34M4.9%-36.8%3.8 yr
ABCAmerisourceBergen Corpor$32M4.6%4.0 yr
DNTHDianthus Therapeutics, I$31M4.5%+362.6%1.3 yr
AVRAnteris Technologies Glo$30M4.3%+52.5%1.5 yr
CORTCorcept Therapeutics Inc$27M3.9%-64.7%0.3 yr
LIVNLivaNova PLC$27M3.9%+61.8%0.5 yr
TYRATyra Biosciences, Inc.$23M3.3%+311.8%3.3 yr
CELCCelcuity Inc.$22M3.2%+1029.0%0.8 yr
GSKGSK plc$21M3.1%+48.1%2.0 yr
ANIPANI Pharmaceuticals, Inc$20M2.9%+14.9%3.0 yr
ABTAbbott Laboratories$19M2.8%-21.1%1.3 yr
EMBCEmbecta Corp.$16M2.4%-27.1%1.8 yr
ABVXAbivax S.A.$15M2.2%+1681.6%0.5 yr

Portfolio composition (YoY)

Industry mix
Biotechnology41.2%+12.7pp$286M
Medical - Devices12.8%-3.2pp$89M
Specialty Business Services7.1%-2.6pp$49M
Drug Manufacturers - Specialty & Generic6.4%-0.4pp$45M
Information Technology Services5.7%$40M
Drug Manufacturers - General5.5%-1.9pp$38M
Medical - Diagnostics & Research4.9%-11.8pp$34M
Unknown4.8%-3.0pp$33M
Medical - Distribution4.6%$32M
Medical - Instruments & Supplies4.3%-2.8pp$30M
Country
US73.6%-4.4pp
GB8.1%
IE4.9%-5.9pp
Unknown4.8%-3.0pp
AU4.3%+1.7pp
FR3.8%
NL0.5%-0.4pp
Top 5: 26.7% · Top 10: 45.4% · Top 25: 75.0%

Winners

TickerPrev $PnLYoY %
TYRA$4M+0.01B311.8%
DNTH$2M+0.01B362.6%
AVR$9M+0.00B52.5%
TARA$6M+0.00B22.3%
VIR$3M+0.00B38.3%

Losers

TickerPrev $PnLYoY %
ICLR$36M-0.01B-36.8%
EMBC$14M-0.00B-27.1%
BMRN$10M-0.00B-20.1%
TFX$15M-0.00B-12.4%
MMS$32M-0.00B-4.5%

Top buys this quarter · 15

CORT Corcept Therapeutics Incorporanew+$27M
WAY Waystar Holding Corp.+$25M
ICLR ICON Public Limited Company+$20M
AVR Anteris Technologies Global Co+$19M
MMS Maximus, Inc.+$17M
EMBC Embecta Corp.+$16M
ANIP ANI Pharmaceuticals, Inc.+$14M
SION Sionna Therapeutics, Inc.new+$12M
ABVX Abivax S.A.+$10M
ABT Abbott Laboratories+$10M

Top sells this quarter · 15

CI Cigna Corporationexit$46M
SNY Sanofi$35M
CELC Celcuity Inc.$32M
ZBH Zimmer Biomet Holdings, Inc.$29M
KVUE Kenvue Inc.exit$25M
ERAS Erasca, Inc.$22M
OGN Organon & Co.$15M
BTSG BrightSpring Health Services, exit$13M
CRL Charles River Laboratories Intexit$9M
CNC Centene Corporationexit$9M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$694M73+42.54%+17.59%+24.95%+0.08B
2025-12-31$603M65+25.63%+17.72%+7.91%+0.13B
2025-09-30$395M51-3.82%+17.52%-21.34%+0.10B
2025-06-30$249M49-13.22%+14.94%-28.17%-0.07B
2025-03-31$330M53-16.26%+8.30%-24.57%+0.01B
2024-12-31$355M51+8.52%+24.89%-16.36%+0.15B
2024-09-30$223M38+27.95%+36.04%-8.09%-0.06B
2024-06-30$265M46+3.97%+24.49%-20.53%-0.01B
2024-03-31$287M48+19.13%+29.62%-10.49%-0.17B
2023-12-31$388M39+0.88%+26.18%-25.29%+0.04B
2023-09-30$323M52+2.17%+21.57%-19.40%+0.08B
2023-06-30$283M41+10.01%+19.42%-9.41%+0.06B
2023-03-31$202M44-11.75%-7.82%-3.93%+0.02B
2022-12-31$180M39+9.16%+7.56%+1.60%-0.08B
2022-09-30$234M43-5.78%-4.93%-0.85%-0.00B
2022-06-30$254M59-13.09%-16.11%+3.02%+0.04B