PRME
Prime Medicine, Inc.Healthcare·Biotechnology
$3.55
$641M market cap
Revenue
$1.7M
Free Cash Flow
$-80.5M
Rev Growth
+0.0%
FCF Margin
-4750.3%
P/FCF
--
EV/FCF
--
Fwd EV/EBITDA
--
Fair Value
--
Upside
--
Prime Medicine, Inc., a biotechnology company, delivers genetic therapies to address diseases by deploying gene editing technology. It offers Prime Editors with a Prime Editor protein, comprising a fusion between a Cas protein and a reverse transcriptase enzyme; and a pegRNA, which targets the Prime Editor to a specific genomic location and provides a template for making the desired edit to the target DNA sequence. The company was incorporated in 2019 and is headquartered in Cambridge, Massachus
2-Year Price History
$2.97-54.8%
Quarterly Financials & Projections
Quarterly Waterfall ($ M)
| Period | Rev | EBITDA | OpIn | NI | OCF | FCF | CapEx | Cash | Debt | Shares | ROIC | IntCov | EV/EBITDA | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Act | 2026-Q1 | 0.9 | -48.8 | -50.7 | -49.1 | -42.7 | -42.9 | -0.2 | 135.5 | 114.5 | 177.1 | -176.9% | -- | -- |
| Act | 2025-Q4 | 0.8 | -46.7 | -48.6 | -46.1 | -37.3 | -37.6 | -0.3 | 177.7 | 116.4 | 148.8 | -124.9% | -- | -- |
Valuation & Metrics
Market Stats
Price$3.55
Market Cap$641M
Enterprise Value$620M
P/S Ratio378.5x
P/FCF--
EV/FCF--
FCF Margin (TTM)-4750.3%
FCF Yield-12.6%
Dividend Yield (TTM)0.2%
Annual Dilution0.0%
CurrencyUSD
TTM Financial Snapshot
Revenue$1.7M
Net Income$-95.2M
Free Cash Flow$-80.5M
Revenue Growth (YoY)+0.0%
EBITDA Margin-5639.3%
Net Margin-5619.9%
FCF Margin-4750.3%
CapEx % of Revenue29.8%
SBC % of Revenue266.5%
ROIC-150.9%
WC Change % Rev203.0%
Interest Coverage--
Forward Outlook & Risk
Short Interest
Short % of Float--
Short Shares30.4M
Days to Cover18.7
Change (vs Prior)+0.4%
Need at least 2 settlement dates for chart
Employees
Headcount214
Revenue / Employee$7,916
Gross Profit / Employee$-757
Cash Runway
20.2months
WATCH
Institutional Ownership
Headline & net flow
NEUTRAL
Net flow · —still filing
No float data — flow unavailable.
Ownership composition
Active
47.5%(+29.2% YoY)
170 filers
hedge / family / endowment
Retail funds
—
Fidelity, Schwab, 401(k)
Passive
16.4%(+12.2% YoY)
13 filers
Vanguard, iShares, SPDR
Market makers
0.5%(+0.5% YoY)
5 filers
Citadel, Susquehanna
Insiders
—
Form 4 — latest per insider
ActiveRetail fundsPassiveMarket makersRetail direct
Top holders
| Fund | $ value | Cost basis | Δ QoQ | Δ YoY | α life | Fund AUM |
|---|---|---|---|---|---|---|
| Alphabet Inc. | $57.6M | $15.43 | +$0 | +$5.2M | +1.4% | $4.02B |
| BlackRock, Inc.Passive | $29.6M | $3.93 | +$810K | +$14.6M | -0.2% | $5.69T |
| STATE STREET CORPPassive | $22.1M | $5.43 | +$4.3M | +$18.1M | -0.2% | $2.89T |
| ARK Investment Management LLC | $21.7M | $8.77 | +$3.1M | +$11.0M | -1.7% | $12.86B |
| T. Rowe Price Investment Management, Inc. | $19.1M | $5.10 | −$1.8M | +$4.7M | -1.3% | $145.22B |
| VANGUARD CAPITAL MANAGEMENT LLCPassive | $15.6M | $3.48 | +$15.6M | +$15.6M | — | $4.04T |
| BALYASNY ASSET MANAGEMENT LLC | $14.3M | $3.49 | +$3.5M | +$14.3M | -0.4% | $48.01B |
| Casdin Capital, LLC | $11.0M | $7.21 | +$0 | +$9.7M | -3.1% | $1.32B |
| Woodline Partners LP | $10.5M | $5.67 | +$2K | +$10.5M | -0.1% | $26.43B |
| Sumitomo Mitsui Trust Group, Inc. | $10.2M | $10.99 | −$1.1M | +$51K | +1.8% | $154.47B |
| Nikko Asset Management Americas, Inc. | $10.2M | $10.99 | −$1.1M | +$51K | -1.1% | $7.07B |
| UBS Group AG | $10.1M | $3.86 | +$1.6M | +$9.6M | -0.3% | $562.11B |
| GEODE CAPITAL MANAGEMENT, LLCPassive | $9.6M | $7.16 | +$401K | +$4.2M | +2.3% | $1.61T |
| ADAR1 Capital Management, LLC | $6.9M | $3.48 | +$6.9M | +$6.9M | +8.3% | $1.64B |
| FMR LLC | $6.2M | $18.42 | −$1.4M | −$6.9M | -0.0% | $1.89T |
| Redmile Group, LLC | $5.5M | $11.55 | +$5.2M | −$1.7M | -5.7% | $1.51B |
| TWO SIGMA INVESTMENTS, LP | $5.5M | $4.82 | −$197K | +$4.6M | -0.9% | $117.03B |
| D. E. Shaw & Co., Inc. | $4.8M | $5.48 | −$549K | +$4.8M | -0.3% | $118.02B |
| FARALLON CAPITAL MANAGEMENT LLC | $4.3M | $5.77 | +$0 | +$1.7M | -0.4% | $15.27B |
| GOLDMAN SACHS GROUP INC | $3.4M | $3.87 | −$2.7M | +$2.5M | -0.2% | $760.93B |
Cost basis is a volume-weighted estimate from accumulation periods within our 13F history; holders who built their position before our window started will show a stale basis. % above the cost basis is the unrealized gain at the current price.
Trading behavior
Smart-money alpha (lifetime, %/qtr)BULLISH
Holders
-0.28%
avg per quarter
Holders (ex-self)
-0.00%
excl. this stock
Buyers (this Q)
+0.80%
105 buyers · $0.06B in
Sellers (this Q)
-0.06%
54 sellers · $0.02B out
alpha coverage: 94% of $ has a lifetime-alpha record
Holder behavior on this stocksource: stock
On big dips (−10%+)
+10.7%
how holders react when this stock falls
On quiet Qs
+25.8%
−10% to +10% baseline
On rallies (+10%+)
-15.9%
how they react when this stock rises
Holders' portfolio flow this Q
+10.1%
inflows — adds are organic
Sellers' portfolio flow this Q
+4.2%
Sellers grew AUM elsewhere — opinionated cut of this stock.
▸ Compare to holder-profile behavior (across all their stocks)
Holder dip (any stock)
-4.4%
Holder mid (any stock)
-5.3%
Holder rally (any stock)
-8.6%
Biggest decreases this quarter
GOLDMAN SACHS GROUP INC−$2.7Mα-0.2Point72 Asset Management, L.P.exited−$1.9MT. Rowe Price Investment Management, Inc.−$1.8Mα-1.3FMR LLC−$1.4Mα-0.0Sumitomo Mitsui Trust Group, Inc.−$1.1Mα+1.8Nikko Asset Management Americas, Inc.−$1.1Mα-1.1Verition Fund Management LLCexited−$1.0MDARK FOREST CAPITAL MANAGEMENT LPexited−$784KJump Financial, LLCexited−$597KD. E. Shaw & Co., Inc.−$549Kα-0.3
New buyers this quarter
Top-5 holders · 43.9%
Alphabet Inc.--
BlackRock, Inc.--
STATE STREET CORP--
ARK Investment Management LLC--
T. Rowe Price Investment Management, Inc.--
Top Holders Over Time
5-year share-count history (top 10 holders by peak, incl. exited) + price
hover the chart for per-quarter detailprice (right axis)
Alphabet Inc.16.6MFMR LLC1.8MT. Rowe Price Investment Management, Inc.5.5MSumitomo Mitsui Trust Group, Inc.2.9MNikko Asset Management Americas, Inc.2.9MPRICE T ROWE ASSOCIATES INC /MD/134KARK Investment Management LLC6.2MRedmile Group, LLC1.6MMWG Management Ltd.—FIL Ltd115K
Analyst Coverage
Analyst Coverage
Analyst Ratings
5
4
Buy: 5Hold: 4Consensus: Buy
Corporate
Insider Trading (last 12mo)
Open-market only (Form 4 P-Purchase + S-Sale). Excludes grants, option exercises, tax withholding, gifts.
Major holders (≥10% beneficial owners)
Buys ($, 12mo)
$35.11M
8 txns · 5 insiders · 10,674,900 sh
Sells ($, 12mo)
$0
0 txns · 0 insiders · 0 sh
Recent transactions
| Date | Side | Insider | Title | Shares | Price | Dollars | Owned $ |
|---|---|---|---|---|---|---|---|
| 2025-08-01 | BUY | ARCH Venture Partners X, LLC | 10 percent owner | 3,030,300 | $3.30 | $10.00M | $20.56M |
| 2025-08-01 | BUY | ARCH Venture Partners XII, LLC | 10 percent owner | 3,030,300 | $3.30 | $10.00M | $20.56M |
| 2025-08-01 | BUY | GV 2021 GP, L.L.C. | 10 percent owner | 1,500,000 | $3.30 | $4.95M | $10.77M |
| 2025-08-01 | BUY | NELSEN ROBERT | director, 10 percent owner: | 3,030,300 | $3.30 | $10.00M | $20.56M |
| 2025-06-30 | BUY | Liu David R. | 10 percent owner | 21,000 | $2.52 | $53K | $50.92M |
| 2025-06-23 | BUY | Liu David R. | 10 percent owner | 21,000 | $2.16 | $45K | $43.72M |
| 2025-06-16 | BUY | Liu David R. | 10 percent owner | 21,000 | $1.49 | $31K | $30.01M |
| 2025-06-11 | BUY | Liu David R. | 10 percent owner | 21,000 | $1.60 | $34K | $32.27M |
Order Flow (FINRA, ~3w lag)
35.3%retail-1.4pp
11.9%dark+0.3pp
week of 2026-04-13
Off-exchange volume from FINRA. Retail = non-ATS (wholesaler PFOF + broker internalization). Dark = ATS (dark-pool crossing networks, institutional). Lit-exchange = remainder.
Filing Risk Analysis
Filing Risk Scores
Prime Medicine, Inc.: A Precarious Burn Towards Insolvency and IP Paralysis
Overall Risk
9/10
Fraud
3/10
Dilution
9/10
Insolvency
10/10
Earnings Overstated
2/10
Hidden Liabilities
5/10
Legal
9/10
Audit Warnings
10/10
Hidden Upside
4/10
Contextually Acceptable
3/10