Stocks/Funds/CIK 1839209

Darwin Global Management, Ltd.

concentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1839209
Assets
$1.19B
+355.5% YoY
Holdings
5
Lifetime alpha vs market
+4.92% annual
Average hold time
0.4 yr
median 0.3 yr

Quarterly history

Cum return +126% vs S&P +91% · α +35% lifetimeAUM $1.2B · peak $1.3BFlow $-26M (-2%)2020-122021-122022-122023-122024-122025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-22.71%
trims when stocks drop
when a holding falls −10%+
Middle response
+27.08%
steady accumulation
Rally response
-14.77%
trims into rallies
when a holding rises +10%+

Top positions · 5

Ticker$ value% portYoYHold time
BLTEBelite Bio, Inc$456M38.2%+140.8%0.5 yr
ABVXAbivax S.A.$352M29.5%+1681.6%0.8 yr
RVMDRevolution Medicines, In$205M17.2%+175.0%0.3 yr
ROIVRoivant Sciences Ltd.$180M15.0%+174.5%0.3 yr
DNTHDianthus Therapeutics, I$1M0.1%+362.6%0.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology100.0%+0.0pp$1.19B
Country
US55.5%+49.3pp
FR29.5%
GB15.0%-78.8pp
Top 5: 100.0% · Top 10: 100.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 5

RVMD Revolution Medicines, Inc.new+$215M
ROIV Roivant Sciences Ltd.new+$188M
ABVX Abivax S.A.+$352M
BLTE Belite Bio, Inc+$456M
DNTH Dianthus Therapeutics, Inc.new+$1M

Top sells this quarter · 3

CDTX Cidara Therapeutics, Inc.exit$0M
WVE Wave Life Sciences Ltd.exit$53M
CAPR Capricor Therapeutics, Inc.exit$24M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$1.19B5+151.52%+17.59%+133.93%-0.03B
2025-12-31$1.30B5+131.46%+17.72%+113.74%+0.27B
2025-09-30$700M4+18.60%+17.52%+1.08%-0.38B
2025-06-30$459M4-40.44%+14.94%-55.38%+0.26B
2025-03-31$262M2-27.29%+8.30%-35.59%+0.12B
2024-12-31$161M5-9.21%+24.89%-34.10%-0.19B
2024-09-30$463M4+4.98%+36.04%-31.06%-0.27B
2024-06-30$622M8-23.82%+24.49%-48.31%-0.09B
2024-03-31$751M12+13.29%+29.62%-16.34%+0.20B
2023-12-31$509M8+11.45%+26.18%-14.73%+0.26B
2023-09-30$284M3+31.00%+21.57%+9.43%-0.24B
2023-06-30$612M3+40.51%+8.68%+31.83%+0.10B
2023-03-31$366M4+6.47%+7.46%-0.98%+0.19B
2022-12-31$161M4+2.32%+7.56%-5.24%+0.09B
2022-09-30$66M2-0.12B
2022-06-30$188M1+0.08B