Stocks/Funds/CIK 1789778

Blue Water Life Science Advisors, LLC

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1789778
Assets
$125M
+23.6% YoY
Holdings
10
Lifetime alpha vs market
-15.65% annual
Average hold time
2.7 yr
median 2.1 yr

Quarterly history

Cum return -23% vs S&P +52% · α -75% lifetimeAUM $125M · peak $327MFlow $-28M (-17%)2020-122021-122022-122023-122024-122025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-3.88%
trims when stocks drop
when a holding falls −10%+
Middle response
-12.58%
baseline attrition
Rally response
-3.66%
trims into rallies
when a holding rises +10%+

Top positions · 10

Ticker$ value% portYoYHold time
TXG10x Genomics, Inc.$23M18.6%+143.2%1.5 yr
GHGuardant Health, Inc.$22M17.9%+116.8%5.5 yr
CDNACareDx, Inc$16M13.0%-2.2%3.8 yr
ADPTAdaptive Biotechnologies$14M11.2%+86.8%4.3 yr
TWSTTwist Bioscience Corpora$13M10.5%+21.0%1.3 yr
PSNLPersonalis, Inc.$11M8.6%+81.5%1.8 yr
NTRANatera, Inc.$9M7.2%+41.4%5.5 yr
QTRXQuanterix Corporation$8M6.0%-45.9%2.5 yr
TEMTempus AI, Inc.$7M5.7%-6.3%1.0 yr
BLLNBillionToOne, Inc.$2M1.3%0.3 yr

Portfolio composition (YoY)

Industry mix
Medical - Diagnostics & Research58.5%-16.9pp$73M
Medical - Healthcare Information Services24.2%$30M
Biotechnology11.2%-4.6pp$14M
Medical - Devices6.0%+3.6pp$8M
Country
US100.0%+0.0pp
Top 5: 71.3% · Top 10: 100.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
GH$30M+0.03B116.8%
ADPT$16M+0.01B86.8%
NTRA$29M+0.01B41.4%
PSNL$4M+0.00B81.5%
CDNA$13M-0.00B-2.2%

Losers

TickerPrev $PnLYoY %
QTRX$2M-0.00B-45.9%
CDNA$13M-0.00B-2.2%

Top buys this quarter · 4

CDNA CareDx, Inc+$7M
TEM Tempus AI, Inc.+$3M
BLLN BillionToOne, Inc.new+$2M
QTRX Quanterix Corporation+$8M

Top sells this quarter · 6

NTRA Natera, Inc.$19M
ADPT Adaptive Biotechnologies Corpo$10M
GH Guardant Health, Inc.$10M
GRAL GRAIL, Inc.exit$5M
TWST Twist Bioscience Corporation$12M
TXG 10x Genomics, Inc.$13M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$125M10+57.19%+17.59%+39.60%-0.03B
2025-12-31$159M9+67.64%+17.72%+49.92%+0.03B
2025-09-30$110M7+43.70%+17.52%+26.18%-0.03B
2025-06-30$126M8+61.83%+14.94%+46.89%+0.00B
2025-03-31$101M7+34.72%+8.30%+26.41%-0.01B
2024-12-31$113M9+31.85%+24.89%+6.96%-0.01B
2024-09-30$114M8-12.07%+36.04%-48.10%-0.01B
2024-06-30$103M8-58.80%+24.49%-83.29%-0.01B
2024-03-31$106M8-72.45%+29.62%-102.08%-0.01B
2023-12-31$114M9-80.07%+26.18%-106.24%+0.04B
2023-09-30$106M7-40.18%+21.57%-61.74%+0.02B
2023-06-30$148M7+25.68%+19.42%+6.26%+0.04B
2023-03-31$151M8+32.05%-7.82%+39.87%+0.04B
2022-12-31$149M8+109.17%+7.56%+101.61%-0.37B
2022-09-30$248M9+19.66%-4.93%+24.58%+0.03B
2022-06-30$184M9-27.04%-16.11%-10.93%+0.03B