Stocks/Funds/CIK 1727492

Caligan Partners LP

concentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1727492
Assets
$1.41B
+195.0% YoY
Holdings
24
Lifetime alpha vs market
+30.12% annual
Average hold time
1.1 yr
median 0.6 yr

Quarterly history

Cum return +317% vs S&P +77% · α +240% lifetimeAUM $1.4B · peak $1.4BFlow $254M (+23%)2022-122023-062023-122024-062024-122025-062025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
+0.23%
adds when stocks drop
when a holding falls −10%+
Middle response
+4.00%
steady accumulation
Rally response
+2.37%
adds into rallies
when a holding rises +10%+

Top positions · 24

Ticker$ value% portYoYHold time
LQDALiquidia Corporation$306M21.7%+155.9%3.5 yr
ABVXAbivax S.A.$163M11.5%+1681.6%1.5 yr
RVMDRevolution Medicines, In$161M11.4%+175.0%1.3 yr
PCVXVaxcyte, Inc.$120M8.5%+53.9%0.5 yr
XENEXenon Pharmaceuticals In$81M5.7%+73.3%0.8 yr
MLYSMineralys Therapeutics, $75M5.3%+70.6%2.0 yr
EXELExelixis, Inc.$67M4.7%+16.2%3.3 yr
TNGXTango Therapeutics, Inc.$50M3.6%+1427.0%0.5 yr
TYRATyra Biosciences, Inc.$49M3.5%+311.8%1.3 yr
SYRESpyre Therapeutics, Inc.$44M3.1%+212.5%0.3 yr
ADMAADMA Biologics, Inc.$43M3.0%-54.6%2.0 yr
LBRXLB Pharmaceuticals Inc C$35M2.4%0.3 yr
VORVor Biopharma Inc.$34M2.4%+24.3%0.5 yr
$31M2.2%0.3 yr
IRDOpus Genetics, Inc.$28M2.0%+363.4%0.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology94.6%+6.8pp$1.34B
Unknown3.9%+3.1pp$55M
Medical - Devices1.5%-3.0pp$21M
Country
US76.9%+1.8pp
FR13.5%+11.8pp
CA5.7%
Unknown3.9%+3.1pp
Top 5: 58.8% · Top 10: 78.9% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
LQDA$120M+0.19B155.9%
ABVX$8M+0.13B1681.6%
RVMD$16M+0.03B175.0%
MLYS$34M+0.02B70.6%
EXEL$56M+0.01B16.2%

Losers

TickerPrev $PnLYoY %
ANIK$22M-0.00B-3.5%

Top buys this quarter · 15

XENE Xenon Pharmaceuticals Inc.+$49M
SYRE Spyre Therapeutics, Inc.new+$44M
RVMD Revolution Medicines, Inc.+$36M
LBRX LB Pharmaceuticals Inc Common new+$35M
IRD Opus Genetics, Inc.new+$28M
MBX MBX Biosciences, Inc. Common Snew+$25M
PCVX Vaxcyte, Inc.+$21M
VOR Vor Biopharma Inc.+$18M
IVA Inventiva S.A.+$17M
ADMA ADMA Biologics, Inc.+$43M

Top sells this quarter · 5

TNGX Tango Therapeutics, Inc.$33M
ELDN Eledon Pharmaceuticals, Inc.exit$2M
SPRB Spruce Biosciences, Inc.exit$1M
exit$0M
RAPT RAPT Therapeutics, Inc.exit$0M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$1.41B24+131.88%+17.59%+114.28%+0.25B
2025-12-31$1.09B20+141.56%+17.72%+123.84%+0.17B
2025-09-30$721M16+82.76%+17.52%+65.24%-0.20B
2025-06-30$515M16+1.99%+14.94%-12.95%+0.06B
2025-03-31$479M16-5.16%+8.30%-13.46%+0.04B
2024-12-31$395M14+3.01%+24.89%-21.88%+0.09B
2024-09-30$315M12+49.41%+36.04%+13.37%-0.11B
2024-06-30$428M13+43.69%+24.49%+19.20%+0.09B
2024-03-31$378M12+71.75%+29.62%+42.13%+0.02B
2023-12-31$297M11+58.06%+26.18%+31.88%+0.02B
2023-09-30$196M12-3.81%-3.22%-0.58%+0.04B
2023-06-30$165M12+5.57%+8.68%-3.11%+0.01B
2023-03-31$143M11+10.50%+7.46%+3.05%+0.01B
2022-12-31$120M11