Stocks/Funds/CIK 1704132

Foresite Capital Management IV, LLC

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1704132
Assets
$237M
+113.5% YoY
Holdings
8
Lifetime alpha vs market
-12.87% annual
Average hold time
2.1 yr
median 1.4 yr

Quarterly history

Cum return -12% vs S&P +52% · α -64% lifetimeAUM $237M · peak $921MFlow $13M (+5%)2017-122019-032020-062021-092022-122024-032025-062026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-7.08%
trims when stocks drop
when a holding falls −10%+
Middle response
+1.01%
steady accumulation
Rally response
+0.10%
adds into rallies
when a holding rises +10%+

Top positions · 8

Ticker$ value% portYoYHold time
PHVSPharvaris N.V.$135M56.9%+79.9%5.3 yr
CYTKCytokinetics, Incorporat$33M14.0%+64.0%3.5 yr
EIKNEikon Therapeutics, Inc.$21M8.7%0.3 yr
LYELLyell Immunopharma, Inc.$16M6.8%1.0 yr
RLAYRelay Therapeutics, Inc.$10M4.2%+279.8%2.8 yr
XENEXenon Pharmaceuticals In$9M3.9%+73.3%1.3 yr
ALECAlector, Inc.$8M3.5%+74.8%1.5 yr
MAZEMaze Therapeutics, Inc.$5M2.0%+171.1%1.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology100.0%+7.8pp$237M
Country
NL56.9%-5.4pp
US39.1%+9.2pp
CA3.9%
Top 5: 90.6% · Top 10: 100.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
PHVS$69M+0.06B79.9%
MAZE$23M+0.04B171.1%
RLAY$3M+0.01B279.8%

Losers

TickerPrev $PnLYoY %

Top buys this quarter · 2

EIKN Eikon Therapeutics, Inc. Commonew+$21M
CYTK Cytokinetics, Incorporated+$3M

Top sells this quarter · 1

MAZE Maze Therapeutics, Inc.$11M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$237M8+109.13%+17.59%+91.54%+0.01B
2025-12-31$230M7+71.81%+17.72%+54.09%+0.01B
2025-09-30$183M6+17.71%+17.52%+0.19%-0.01B
2025-06-30$124M6-27.76%+14.94%-42.70%+0.00B
2025-03-31$111M5-43.93%+8.30%-52.23%+0.02B
2024-12-31$109M4-32.44%+24.89%-57.32%-0.02B
2024-09-30$153M5+2.51%+36.04%-33.52%+0.01B
2024-06-30$149M4+8.60%+24.49%-15.89%-0.02B
2024-03-31$198M5+61.97%+29.62%+32.35%+0.01B
2023-12-31$198M5+20.64%+26.18%-5.54%-0.03B
2023-09-30$180M7+1.87%+21.57%-19.70%-0.03B
2023-06-30$203M7-29.74%+19.42%-49.16%-0.04B
2023-03-31$193M8-53.82%-7.82%-46.00%+0.02B
2022-12-31$234M8+7.50%+7.56%-0.06%-0.10B
2022-09-30$311M8-29.21%-4.93%-24.28%+0.05B
2022-06-30$371M8-15.78%-16.11%+0.33%+0.07B