Stocks/Funds/CIK 1274403

ARCH Venture Management, LLC

long-term holderconcentrated
Quarterly 13F filings · Latest period 2026-03-31 · CIK 1274403
Assets
$677M
+228.3% YoY
Holdings
10
Lifetime alpha vs market
-24.40% annual
Average hold time
1.8 yr
median 1.6 yr

Quarterly history

Cum return -50% vs S&P +52% · α -102% lifetimeAUM $677M · peak $945MFlow $-41M (-6%)2018-122019-122021-122022-122023-122024-122025-122026-03
AUM ($B)fundS&P 500(gap = α)/ Flow in/out

Behavior signals (lifetime)

Dip response
-1.73%
trims when stocks drop
when a holding falls −10%+
Middle response
-5.39%
baseline attrition
Rally response
-8.86%
trims into rallies
when a holding rises +10%+

Top positions · 10

Ticker$ value% portYoYHold time
MAZEMaze Therapeutics, Inc.$123M18.2%+171.1%1.3 yr
RAPPRapport Therapeutics, In$117M17.2%+212.0%2.0 yr
VIRVir Biotechnology, Inc.$116M17.1%+38.3%1.0 yr
ERASErasca, Inc.$115M16.9%+1081.0%4.5 yr
BEAMBeam Therapeutics Inc.$108M16.0%+22.0%2.0 yr
LYELLyell Immunopharma, Inc.$65M9.6%1.0 yr
GENBGenerate Biomedicines, I$24M3.6%0.3 yr
TXG10x Genomics, Inc.$5M0.7%+143.2%0.5 yr
GOSSGossamer Bio, Inc.$3M0.4%-70.1%2.8 yr
QTTBQ32 Bio Inc.$2M0.3%+289.1%2.3 yr

Portfolio composition (YoY)

Industry mix
Biotechnology95.7%-3.8pp$648M
Asset Management3.6%$24M
Medical - Healthcare Information Services0.7%$5M
Country
US100.0%+0.0pp
Top 5: 85.4% · Top 10: 100.0% · Top 25: 100.0%

Winners

TickerPrev $PnLYoY %
ERAS$15M+0.16B1081.0%
RAPP$38M+0.08B212.0%
MAZE$45M+0.08B171.1%
BEAM$89M+0.02B22.0%
QTTB$1M+0.00B289.1%

Losers

TickerPrev $PnLYoY %
GOSS$9M-0.01B-70.1%

Top buys this quarter · 2

GENB Generate Biomedicines, Inc.new+$24M
LYEL Lyell Immunopharma, Inc.+$65M

Top sells this quarter · 2

ERAS Erasca, Inc.$41M
TXG 10x Genomics, Inc.$11M

Quarterly history (TTM returns)

PeriodAUM# PosReturn (1yr)SPY (1yr)Alpha (1yr)Flow
2026-03-31$677M10+136.72%+17.59%+119.13%-0.04B
2025-12-31$652M9+50.55%+17.72%+32.83%+0.01B
2025-09-30$492M9+4.05%+17.52%-13.47%-0.02B
2025-06-30$299M11-37.75%+14.94%-52.70%+0.10B
2025-03-31$206M9-46.51%+8.30%-54.81%+0.04B
2024-12-31$230M9-19.77%+24.89%-44.65%-0.00B
2024-09-30$261M9-6.02%+36.04%-42.06%-0.01B
2024-06-30$266M9-35.81%+24.49%-60.31%+0.20B
2024-03-31$80M8-10.70%+29.62%-40.32%-0.09B
2023-12-31$164M7-33.14%+26.18%-59.32%+0.00B
2023-09-30$154M7-52.19%+21.57%-73.75%+0.04B
2023-06-30$162M6-22.47%+19.42%-41.89%-0.07B
2023-03-31$207M8-56.03%-7.82%-48.21%-0.10B
2022-12-31$390M8-24.72%+7.56%-32.28%-0.19B
2022-09-30$771M10+14.58%-4.93%+19.51%-0.17B
2022-06-30$821M10-35.23%-16.11%-19.12%+0.37B